Volume 16 - Number 3 - 2025-5 - Basic and Clinical Neuroscience

Volume 16, Issue 3 (May & June 2025)

Pathways Mediating Blindsight After V1 Injury: A Systematic Review of Human and Monkey Studies

P. 533-550

‎ 10.32598/bcn.2025.7005.1

Mohammad Reza Balali

, Mohaddeseh Hosseini

, Maryam Khanboloki

, Mohammad Mohammadi

, Amir Mohammad Khorshidvand ^*

, Mohammad Taghi Joghataei

Abstract | Full-Text (PDF) | Full-Text (HTML) (593 Views) | Highlights

Looking at Philosophy for Children and Its Outcomes Through a Neuroscience Lens

P. 551-568

‎ 10.32598/bcn.2024.6110.1

Fariba Khodagholi

, Maryam Alsadat Mousavi ^*

, Yahya Ghaedi

, Shakiba Salarvandian

, Fatemeh Vosoughian

, Mobina Javadi

, Fereshteh Khodagholi

Abstract | Full-Text (PDF) | Full-Text (HTML) (1064 Views) | Highlights

Alpha-mangostin Ameliorates Apoptosis, Inflammation and Oxidative Stress in Cuprizone-induced Demyelination in C57BL/6 Mice

P. 569-582

‎ 10.32598/bcn.2024.799.3

Sara Banaeeyeh

, Bibi Marjan Razavi

, Hossein Hosseinzadeh ^*

Abstract | Full-Text (PDF) | Full-Text (HTML) (261 Views) | Highlights

Histone Deacetylase Class IIb Inhibition Improves Amyloid-β-induced Learning and Memory Deficits in Male Rats

P. 583-594

‎ 10.32598/bcn.2024.2822.2

Zahra Mansouri

, Fereshteh Motamedi

, Fariba Khodagholi

, Maryam Zahmatkesh ^*

Abstract | Full-Text (PDF) | Full-Text (HTML) (244 Views) | Highlights

Short-term Efficacy of Commercial Curcumin Nanomicelle on Cognition, Oxidative Stress and Choline Esterase in Alzheimer’s Disease

P. 595-608

‎ 10.32598/bcn.2024.4970.1

Samira Kazemi

, Narges Hesni Langroudi

, Peyman Hasani Abharian

, Kamran Tavakol

, Mohammad Taghi Joghataei

, Shima Tavakol ^*

, Sepide Arbabi Bidgoli

Abstract | Full-Text (PDF) | Full-Text (HTML) (517 Views) | Highlights

Vismodegib Improved Therapy of Medulloblastoma by Targeting Sonic Hedgehog Signaling Pathway on DAOY Medulloblastoma Cell Line

P. 609-618

‎ 10.32598/bcn.2024.6423.1

Masume Behruzi

, Mehrdad Ghorbanlou

, Ronak Shabani

, Auob Rustamzadeh

, Enam Alhagh Gorgich

, Elham Seidkhani

, Farnoosh Usefi

, Mehdi Mehdizadeh

, Fatemeh Moradi ^*

Abstract | Full-Text (PDF) | Full-Text (HTML) (271 Views) | Highlights

Impact of Genotropin on Oxidative Stress, Glutamate, and Nitric Oxide Pathways in a Rat Model of Peripheral Neuropathy

P. 619-632

‎ 10.32598/bcn.2025.6536.1

Sepideh Saffarpour

, Arash Mehraz

, Pargol Sadeghi Tehran

, Farinaz Nasirinezhad ^*

Abstract | Full-Text (PDF) | Full-Text (HTML) (257 Views) | Highlights

Sural/Radial Amplitude Ratio in Healthy Adults: Influence of Anatomical and Demographic Variables

P. 633-640

‎ 10.32598/bcn.2025.6574.1

Fateme Hojjati

, Seyed Mansour Rayegani

, Ali Nazari Nodoushan ^*

, Masume Bayat

, Davood Khavari Ardestani

, Zahra Razzaghi

Abstract | Full-Text (PDF) | Full-Text (HTML) (351 Views) | Highlights

Vitis Vinifera L. Flavones Preserve Mitophagy in the Amyloid-beta 1-42-induced Model of Alzheimer’s Disease Neurodegeneration

P. 641-656

‎ 10.32598/bcn.2025.6592.1

Peng Zhang

, Hui Xiao ^*

Abstract | Full-Text (PDF) | Full-Text (HTML) (228 Views) | Highlights

Determining Pro-oxidant Antioxidant Balance in Febrile Children With and Without Seizure: A Comparative Study

P. 657-666

‎ 10.32598/bcn.2024.6601.1

Mohammad Salari Zare

, Mehran Mir

, Saeideh Sadat Shobeiri

, Houman Tehrani

, Parastoo Amiri

, Mitra Azra Aldaghi

, Kazem Hassanpour ^*

Abstract | Full-Text (PDF) | Full-Text (HTML) (277 Views) | Highlights

Predictors of Quality of Life in Patients With Parkinson’s Disease: A Multicenter Case-control Study

P. 667-676

‎ 10.32598/bcn.2024.6859.1

Aida Moarrefzadeh

, Sadra Sarandili

, Nogol Motamed-Gorji

, Fatemeh Majdolashrafi

, Mohammadhossein Vazirizadeh-Mahabadi

, Seyed Amirhassan Habibi ^*

Abstract | Full-Text (PDF) | Full-Text (HTML) (339 Views) | Highlights

● The patients with PD had significantly lower PDQ-39 scores than healthy controls.
● Deep brain stimulation improved multiple PDQ-39 domains.
● Mobility and stigma were the mostly affected domains by DBS in PD patients.
● The advanced disease stage was linked to a lower PDQ-39 score in PD patients.
● Female sex, older age, and lower education predicted poorer QoL in PD patients.

Plain Language Summary

Parkinson's disease (PD) is a progressive neurological disorder. As the condition progresses, individuals may also encounter difficulties related to emotions, cognitive processes, and the execution of daily tasks, which can significantly affect their quality of life (QoL). In this study, we aimed to measure the effects of PD on the QoL of patients and to assess whether specific variables, such as the disease stage or therapeutic interventions, are related to it. We used the 39-item PD questionnaire (PDQ-39) to assess the PD-related QoL in various areas, including mobility, stigma, emotional well-being, social support, cognition, communication, activities of daily living, and bodily discomfort. The findings indicated that patients experienced a significantly lower PD-related QoL in comparison to their healthy counterparts. The patients who underwent deep brain stimulation (DBS) exhibited higher improvement in domains such as mobility, activities of daily living, and cognition. Female patients, older patients, and those at advanced stages of PD were more likely to report a poor QoL. These results indicate the multifaceted impact of PD on various QoL aspects, and not only on motor functions, and suggest that patients from specific demographic groups may require more support. Additionally, the results demonstrate the potential effects of DBS in ameliorating the life experiences of individuals with PD. An in-depth understanding of these variables can assist healthcare professionals and caregivers in delivering tailored care and facilitating more informed decisions regarding PD management.