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1- Department of Neurology, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
2- Department of Pediatrics, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
3- Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
4- Iranian Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Background: A benign condition known as a febrile seizure (FS) occurs between the ages of six and sixty months when the patient has a fever of at least 38 oC, is not suffering from a CNS infection or metabolic disorder, and has no prior history of febrile seizures. It is thought that oxidative stress contributes to the emergence of a number of neurodegenerative disorders. In light of this, the current study examined the pro-oxidant antioxidant balance (PAB) in febrile children with and without seizures.
Methods: The current cross-sectional study was done in the Heshmatieh hospital of Sabzevar University of Medical Sciences, between March 2020 and March 2021. Forty febrile children with a temperature of 38 degrees and above (F) and forty febrile children who experienced their first seizure (FS) were included in the study, and blood samples were taken from all patients. The Pro-oxidant-antioxidant balance was evaluated using a special PAB assay. Pro-oxidant-antioxidant ratio values were expressed in HK.
Results: The HK variable in the FS group was 180.43 ± 9.28 and in the F group was 131.83 ± 17.73. In fact, the FS group had a higher mean serum level of PAB than F group (Pvalue <0.05), which indicated that the level of oxidative stress in patients with febrile seizure was higher than the febrile patients without seizure. 
Conclusion: It seems that the serum antioxidant level is related to the possibility of seizures in febrile children.
Type of Study: Original | Subject: Clinical Neuroscience
Received: 2024/05/27 | Accepted: 2024/06/5

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