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Nastaran Asri1 
, Behrooz Ahmadi2 , Nazanin Taraghikhah2 , Hamidreza Houri3 , Somayeh Jahani-Sherafat4 , Mostafa Rezaei-Tavirani5 , Mohadeseh Mahmoudi Ghehsareh1 , Ayad Bahadorimonfared6 , Mohammad Rostami-Nejad * 1
, Behrooz Ahmadi2 , Nazanin Taraghikhah2 , Hamidreza Houri3 , Somayeh Jahani-Sherafat4 , Mostafa Rezaei-Tavirani5 , Mohadeseh Mahmoudi Ghehsareh1 , Ayad Bahadorimonfared6 , Mohammad Rostami-Nejad * 1
1- Celiac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5- Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6- Department of Health & Community Medicine,Faculty of Medicine,Shahid Beheshti University of Medical Sciences,Tehran,Iran
2- Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5- Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6- Department of Health & Community Medicine,Faculty of Medicine,Shahid Beheshti University of Medical Sciences,Tehran,Iran
Abstract:
Background: Inflammatory responses in celiac disease (CD) may lead to immune dysregulation and sleep disturbances. Additionally, impaired tryptophan metabolism within the gastrointestinal tract has been identified as being associated with chronic intestinal inflammation. This study examines the link between sleep disorders, tryptophan levels, and cytokine profiles in CD patients.
Methods: A cohort study involving 76 adult CD patients (mean age 40.3 years) was conducted from March to December 2022. Sleep quality was assessed with the Pittsburgh Sleep Quality Index questionnaire. Plasma tryptophan levels were measured using HPLC, and serum TNF-α and IL-10 levels were determined with ELISA. IL-2 and IL-4 expression was evaluated using quantitative real-time PCR.
Results: A significant proportion (63.2%) of CD patients experienced poor sleep quality. Additionally, increasing age was positively correlated with the presence of sleep disturbances. Importantly, CD patients with poor sleep quality had lower plasma Trp levels compared to those with good sleep quality (p<0.0001). Moreover, individuals with poor sleep quality exhibited elevated IL-2 (p=0.03) level in comparison to patients with good sleep quality. Conversely, there was no significant difference observed in IL-4, IL-10 and TNF-α levels between individuals with poor sleep quality and those with good sleep quality.
Conclusions: Low levels of Trp may indicate a potential for Trp supplementation to alleviate sleep disturbances in CD patients. However, further research is needed to understand the underlying mechanisms and evaluate potential interventions.
Methods: A cohort study involving 76 adult CD patients (mean age 40.3 years) was conducted from March to December 2022. Sleep quality was assessed with the Pittsburgh Sleep Quality Index questionnaire. Plasma tryptophan levels were measured using HPLC, and serum TNF-α and IL-10 levels were determined with ELISA. IL-2 and IL-4 expression was evaluated using quantitative real-time PCR.
Results: A significant proportion (63.2%) of CD patients experienced poor sleep quality. Additionally, increasing age was positively correlated with the presence of sleep disturbances. Importantly, CD patients with poor sleep quality had lower plasma Trp levels compared to those with good sleep quality (p<0.0001). Moreover, individuals with poor sleep quality exhibited elevated IL-2 (p=0.03) level in comparison to patients with good sleep quality. Conversely, there was no significant difference observed in IL-4, IL-10 and TNF-α levels between individuals with poor sleep quality and those with good sleep quality.
Conclusions: Low levels of Trp may indicate a potential for Trp supplementation to alleviate sleep disturbances in CD patients. However, further research is needed to understand the underlying mechanisms and evaluate potential interventions.
Type of Study: Original |
Subject:
Behavioral Neuroscience
Received: 2024/08/10 | Accepted: 2024/09/14
Received: 2024/08/10 | Accepted: 2024/09/14
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