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Mohammad Reza Balali1 
, Mohaddeseh Hosseini1 , Maryam Khanboloki1 , Mohammad Mohammadi1 , Amir Mohammad Khorshidvand * 1, Mohammad Taghi Joghataei2
, Mohaddeseh Hosseini1 , Maryam Khanboloki1 , Mohammad Mohammadi1 , Amir Mohammad Khorshidvand * 1, Mohammad Taghi Joghataei2
1- Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
2- Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
2- Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
Abstract:
Objective: Despite injury to area V1 resulting in visual impairment, some patients maintain visual capabilities in an unconscious manner, a phenomenon called blindsight. This systematic review critically evaluates the role of neural pathways that facilitate blindsight.
Methods: The review comprehensively assesses research from online databases. Following the screening process, we employed the JBI critical appraisal checklist and the SYRCLE tool for the assessment of risks in human and animal studies. Two authors conducted separate evaluations of each study. Every disagreement was effectively settled by mutual agreement. We selected 25 articles focusing on the mediating pathways of blindsight.
Results: In humans, the pathways from the Lateral Geniculate Nucleus (LGN) to V5, from the Superior Colliculus (SC) to higher brain areas, and to the remaining segments of V1 are crucial. The pathway that connects the SC, pulvinar, and amygdala is essential for processing emotional visual information. Studies conducted on animals emphasize how important the SC-Pulvinar pathway and the connections between the LGN and extrastriate areas are for developing blindsight.
Conclusion: Individual differences in neuroplasticity, the precise site and timing of the damage, and the amount of time that has passed since the injury all play a major role in the activation of pathways that enable blindsight. This demonstrates a complicated system that successfully lessens the loss of the primary visual cortex, highlighting the necessity of developing rehabilitation plans that are specific to each individual with visual impairments.
Methods: The review comprehensively assesses research from online databases. Following the screening process, we employed the JBI critical appraisal checklist and the SYRCLE tool for the assessment of risks in human and animal studies. Two authors conducted separate evaluations of each study. Every disagreement was effectively settled by mutual agreement. We selected 25 articles focusing on the mediating pathways of blindsight.
Results: In humans, the pathways from the Lateral Geniculate Nucleus (LGN) to V5, from the Superior Colliculus (SC) to higher brain areas, and to the remaining segments of V1 are crucial. The pathway that connects the SC, pulvinar, and amygdala is essential for processing emotional visual information. Studies conducted on animals emphasize how important the SC-Pulvinar pathway and the connections between the LGN and extrastriate areas are for developing blindsight.
Conclusion: Individual differences in neuroplasticity, the precise site and timing of the damage, and the amount of time that has passed since the injury all play a major role in the activation of pathways that enable blindsight. This demonstrates a complicated system that successfully lessens the loss of the primary visual cortex, highlighting the necessity of developing rehabilitation plans that are specific to each individual with visual impairments.
Type of Study: Review |
Subject:
Behavioral Neuroscience
Received: 2024/10/16 | Accepted: 2024/11/19
Received: 2024/10/16 | Accepted: 2024/11/19
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