Predictors of Quality of Life in Patients with Parkinson's Disease: A Multicenter Case-Control Study
چکیده:
Background: Parkinson's disease (PD) is a common neurodegenerative disease whose motor and non-motor complication greatly affect a person's quality of life (QoL). This study aims to investigate the QoL of these patients using the PDQ-39 questionnaire and identify the prognostic factors associated with their QoL.
Method: In the current case-control study, the QoL of two groups (211 controls and 211 cases) was investigated and compared using the PDQ-39 questionnaire. Prognostic factors associated with QoL were determined using multivariate logistic regression analysis.
Results: A number of 422 patients with the mean age of 59.8 ± 13.7 years were included in the study. The mean score of PDQ-39 in the case group was significantly higher in all subscales except Social support compared to the control group. The mean score of PDQ-39 was significantly higher in the patients with non-DBS (53.9 ± 21.1 (than those with DBS (42.22 ± 18.1(, especially in the sub-scales of Mobility, Activities of daily living, Cognition, and Communication. As the stage of the disease increases, the mean score of PDQ-39 in these patients increases significantly. The results of multivariate analysis showed that gender, patient age, smoking, education level, duration of disease, patient stage, and intervention with DBS were significantly related to patients' QoL (P<0.05).
Conclusion: In conclusion, this study highlights the significant impact of DBS on PD patients' QoL, especially in sub-scales of mobility, daily activities, emotional well-being, and cognition. Moreover, identifying the main prognostic factors in QoL (gender, age, smoking status, educational level, disease duration, and stage) can lead to avenues for improving these patients' lives.
Method: In the current case-control study, the QoL of two groups (211 controls and 211 cases) was investigated and compared using the PDQ-39 questionnaire. Prognostic factors associated with QoL were determined using multivariate logistic regression analysis.
Results: A number of 422 patients with the mean age of 59.8 ± 13.7 years were included in the study. The mean score of PDQ-39 in the case group was significantly higher in all subscales except Social support compared to the control group. The mean score of PDQ-39 was significantly higher in the patients with non-DBS (53.9 ± 21.1 (than those with DBS (42.22 ± 18.1(, especially in the sub-scales of Mobility, Activities of daily living, Cognition, and Communication. As the stage of the disease increases, the mean score of PDQ-39 in these patients increases significantly. The results of multivariate analysis showed that gender, patient age, smoking, education level, duration of disease, patient stage, and intervention with DBS were significantly related to patients' QoL (P<0.05).
Conclusion: In conclusion, this study highlights the significant impact of DBS on PD patients' QoL, especially in sub-scales of mobility, daily activities, emotional well-being, and cognition. Moreover, identifying the main prognostic factors in QoL (gender, age, smoking status, educational level, disease duration, and stage) can lead to avenues for improving these patients' lives.
نوع مطالعه: Original |
موضوع مقاله:
Cellular and molecular Neuroscience
دریافت: 1403/5/7 | پذیرش: 1403/5/28
دریافت: 1403/5/7 | پذیرش: 1403/5/28
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