Volume 11, Issue 5 (September & October - Special Issue on Cognitive Neuroscience 2020)                   BCN 2020, 11(5): 619-630 | Back to browse issues page

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R. Bapat P, D. Shekhawat S, A. Husain A, S. Dodkey R, F. Daginawala H, K. Singh L et al . Diagnostic Challenges and Prospects Associated With Zoonotic Tuberculosis of Central Nervous System. BCN 2020; 11 (5) :619-630
URL: http://bcn.iums.ac.ir/article-1-874-en.html
1- Research Centre, Central India Institute of Medical Sciences, Nagpur, Maharashtra, India.

Introduction: The diagnosis of Tuberculous Meningitis (TBM) has remained a challenge due to its insidious onset and the failure of conventional diagnostic tests. The present study aimed to identify the mycobacterial pathogen in the CSF of patients with TBM and a poor prognosis.
Methods: We retrospectively recruited 224 TBM and 34 non-TBM patients admitted to the Central India Institute of Medical Sciences, Nagpur, India, in 2014. The CSF samples of these patients were subjected to a duplex PCR assay for the species-specific identification of the causative pathogen.
Results: M. bovis and infection with M.tuberculosis were detected in 7% (18) and 32.9% (85) of the patients, respectively. Moreover, 14% (36) of the study samples were culture positive; however, the mycobacterial pathogens could not be differentiated to the species level. 
Conclusion: The present study findings emphasized the potentially vital importance of M. bovis identification for appropriate patient management. The obtained data also demonstrated the persistent significance of M. bovis, as a zoonotic pathogen.

Type of Study: Original | Subject: Clinical Neuroscience
Received: 2019/11/29 | Accepted: 2020/04/11 | Published: 2020/09/1

5. https://doi.org/10.1097/01202412-200101000-00011

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