دوره 11، شماره 5 - ( 6-1399 )
جلد 11 شماره 5 صفحات 630-619 |
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R. Bapat P, D. Shekhawat S, A. Husain A, S. Dodkey R, F. Daginawala H, K. Singh L et al . Diagnostic Challenges and Prospects Associated With Zoonotic Tuberculosis of Central Nervous System. BCN 2020; 11 (5) :619-630
URL: http://bcn.iums.ac.ir/article-1-874-fa.html
URL: http://bcn.iums.ac.ir/article-1-874-fa.html
Diagnostic Challenges and Prospects Associated With Zoonotic Tuberculosis of Central Nervous System. مجله علوم اعصاب پایه و بالینی. 1399; 11 (5) :619-630
چکیده:
Introduction: The diagnosis of Tuberculous Meningitis (TBM) has remained a challenge due to its insidious onset and the failure of conventional diagnostic tests. The present study aimed to identify the mycobacterial pathogen in the CSF of patients with TBM and a poor prognosis.
Methods: We retrospectively recruited 224 TBM and 34 non-TBM patients admitted to the Central India Institute of Medical Sciences, Nagpur, India, in 2014. The CSF samples of these patients were subjected to a duplex PCR assay for the species-specific identification of the causative pathogen.
Results: M. bovis and infection with M.tuberculosis were detected in 7% (18) and 32.9% (85) of the patients, respectively. Moreover, 14% (36) of the study samples were culture positive; however, the mycobacterial pathogens could not be differentiated to the species level.
Conclusion: The present study findings emphasized the potentially vital importance of M. bovis identification for appropriate patient management. The obtained data also demonstrated the persistent significance of M. bovis, as a zoonotic pathogen.
نوع مطالعه: Original |
موضوع مقاله:
Clinical Neuroscience
دریافت: 1398/9/8 | پذیرش: 1399/1/23 | انتشار: 1399/6/11
دریافت: 1398/9/8 | پذیرش: 1399/1/23 | انتشار: 1399/6/11
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