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Nasehi F, Khodagholi F, Kaveh N, Maleki A, Zeinaddini-Meymand A, Mousavi M A, et al . Mitochondrial Toxicity by 3-NP Enhanced Susceptibility to Defective Social Behaviors in Male Wistar Rats. BCN 2025; 16 (2) :489-504
URL: http://bcn.iums.ac.ir/article-1-2947-en.html

Introduction: The impaired mitochondrial function in neurons is a principal abnormality in many medical conditions. Behavioral changes are the key aspects that emerge under these conditions. In the current study, we investigated whether social interactions are influenced by 3-nitropropionic acid (3-NP)-induced mitochondrial failure. We also assessed changes in glucocorticoid receptor (GR) and FKBP5 protein levels, cytochrome contents, and monoamine oxidase (MAO) A and B activities in the striatum (ST), hippocampus (HIP), and prefrontal cortex (PFC) of the subjects.
Methods: Adult male Wistar rats were treated with 3-NP. Then, the social and non-social behaviors of 3-NP-treated rats were investigated. Different dissected brain regions were considered regarding GR and FKBP5 protein levels, cytochrome contents, and MAO-A and MAO-B. 
Results: We found a significantly decreased duration of social behaviors and impaired non-social behavioral tests. We detected a decreasing trend in GR and FKBP5 protein levels. Moreover, cytochrome contents and MAO A and B activities decreased in the dissected brain regions.
Conclusion: Impaired social/non-social behaviors and decreased levels of investigated molecular variables in the regions mentioned above after 3-NP treatment might point to processes connecting mitochondrial failure to behavioral impairment, particularly social type.