Volume 16, Issue 2 (March & April- In Press 2025)                   BCN 2025, 16(2): 0-0 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Nasehi F, Khodagholi F, Kaveh N, Maleki A, Zeinaddini-Meymand A, Mousavi M A, et al . The Mitochondrial Toxicity Induced by 3-Nitropropionic Acid Enhanced Susceptibility to Defective Social Behaviors in Male Wistar Rats: Possible Role of Glucocorticoid Receptor and FKBP5. BCN 2025; 16 (2)
URL: http://bcn.iums.ac.ir/article-1-2947-en.html
1- Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
Abstract:  
The impaired mitochondrial function in neurons is a core abnormality in many medical conditions. Behavioral changes are the key aspects that emerge under these conditions. In the current study, we investigated whether social interactions are influenced by 3-nitropropionic acid (3-NP)-induced mitochondrial failure. We also assessed changes in glucocorticoid receptor and FKBP5 protein levels, cytochrome contents, and monoamine oxidase A and B activities in the striatum, hippocampus, and prefrontal cortex of the subjects. Adult male Wistar rats were treated with 3-NP. The social and non-social behaviors of 3-NP-treated rats were investigated. Different dissected brain regions were considered in terms of glucocorticoid receptor and FKBP5 protein levels, cytochrome contents, and monoamine oxidase A and B activities. We found a significantly decreased duration of social behaviors along with impaired non-social behavioral tests in the striatum, hippocampus, and prefrontal cortex. We detected a decreasing trend in the levels of glucocorticoid receptor and FKBP5 protein. Moreover, cytochrome contents and monoamine oxidase A and B activities decreased in the dissected brain regions. Impaired social/non-social behaviors along with decreased levels of investigated molecular variables in the aforementioned regions after 3-NP treatment might point to processes connecting mitochondrial failure to behavioral impairment, particularly social type.
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2024/06/2 | Accepted: 2024/08/7 | Published: 2025/04/21

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2025 CC BY-NC 4.0 | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb