چکیده:
The impaired mitochondrial function in neurons is a core abnormality in many medical conditions. Behavioral changes are the key aspects that emerge under these conditions. In the current study, we investigated whether social interactions are influenced by 3-nitropropionic acid (3-NP)-induced mitochondrial failure. We also assessed changes in glucocorticoid receptor and FKBP5 protein levels, cytochrome contents, and monoamine oxidase A and B activities in the striatum, hippocampus, and prefrontal cortex of the subjects. Adult male Wistar rats were treated with 3-NP. The social and non-social behaviors of 3-NP-treated rats were investigated. Different dissected brain regions were considered in terms of glucocorticoid receptor and FKBP5 protein levels, cytochrome contents, and monoamine oxidase A and B activities. We found a significantly decreased duration of social behaviors along with impaired non-social behavioral tests in the striatum, hippocampus, and prefrontal cortex. We detected a decreasing trend in the levels of glucocorticoid receptor and FKBP5 protein. Moreover, cytochrome contents and monoamine oxidase A and B activities decreased in the dissected brain regions. Impaired social/non-social behaviors along with decreased levels of investigated molecular variables in the aforementioned regions after 3-NP treatment might point to processes connecting mitochondrial failure to behavioral impairment, particularly social type.
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