Volume 15, Issue 2 (March & April 2024)                   BCN 2024, 15(2): 157-164 | Back to browse issues page

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Razmkon A, Abdollahifard S, Rezaei H, Bahadori A R, Eskandarzadeh P, Rastegar Kazerooni A. Effect of Deep Brain Stimulation on Parkinson Disease Dementia: A Systematic Review and Meta-analysis. BCN 2024; 15 (2) :157-164
URL: http://bcn.iums.ac.ir/article-1-2177-en.html
1- Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran.
Introduction: Patients in the early stages of Parkinson disease (PD) may have subtle cognitive deficits, while overt cognitive deficits are usually manifestations of late-stage PD. There is still a debate on the outcome of deep brain stimulation (DBS) on the cognitive function of PD patients. This study aimed to investigate the effect of subthalamic nucleus (STN)-DBS on the dementia of PD patients after surgery compared to medical therapy and other procedures. 
Methods: We searched PubMed, Scopus, Cochrane Library, and Web of Science database on October 2020, with keywords: “Deep brain stimulation,” “Parkinson disease,” “dementia,” and “memory.” Reviews, abstracts, case presentations, and letters were excluded. 
Results: In total, 491 studies were screened after removing the duplicates. The screening results yielded 81 articles to be screened for eligibility. Finally, 6 studies were included in this meta-analysis for synthesis. Overall, 800 patients were included in this meta-analysis, using the Mattis dementia rating scale (MDRS) and descriptive data from the articles extracted to assess global dementia.
Conclusion: Our results suggest that the STN-DBS group showed a larger cognitive decline than the patients receiving the best medical treatment (BMT). However, comparing STN-DBS with globus pallidus interna stimulation and pallidotomy could not demonstrate a significant statistical effect on the global dementia of patients. More long-term studies with larger sample sizes are needed to validate current findings. 
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Type of Study: Review | Subject: Clinical Neuroscience
Received: 2021/05/24 | Accepted: 2022/09/27 | Published: 2024/03/1

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