دوره 15، شماره 2 - ( 12-1402 )
جلد 15 شماره 2 صفحات 164-157 |
برگشت به فهرست نسخه ها
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Razmkon A, Abdollahifard S, Rezaei H, Bahadori A R, Eskandarzadeh P, Rastegar Kazerooni A. Effect of Deep Brain Stimulation on Parkinson Disease Dementia: A Systematic Review and Meta-analysis. BCN 2024; 15 (2) :157-164
URL: http://bcn.iums.ac.ir/article-1-2177-fa.html
URL: http://bcn.iums.ac.ir/article-1-2177-fa.html
Effect of Deep Brain Stimulation on Parkinson Disease Dementia: A Systematic Review and Meta-analysis. مجله علوم اعصاب پایه و بالینی. 1402; 15 (2) :157-164
چکیده:
Introduction: Patients in the early stages of Parkinson disease (PD) may have subtle cognitive deficits, while overt cognitive deficits are usually manifestations of late-stage PD. There is still a debate on the outcome of deep brain stimulation (DBS) on the cognitive function of PD patients. This study aimed to investigate the effect of subthalamic nucleus (STN)-DBS on the dementia of PD patients after surgery compared to medical therapy and other procedures.
Methods: We searched PubMed, Scopus, Cochrane Library, and Web of Science database on October 2020, with keywords: “Deep brain stimulation,” “Parkinson disease,” “dementia,” and “memory.” Reviews, abstracts, case presentations, and letters were excluded.
Results: In total, 491 studies were screened after removing the duplicates. The screening results yielded 81 articles to be screened for eligibility. Finally, 6 studies were included in this meta-analysis for synthesis. Overall, 800 patients were included in this meta-analysis, using the Mattis dementia rating scale (MDRS) and descriptive data from the articles extracted to assess global dementia.
Conclusion: Our results suggest that the STN-DBS group showed a larger cognitive decline than the patients receiving the best medical treatment (BMT). However, comparing STN-DBS with globus pallidus interna stimulation and pallidotomy could not demonstrate a significant statistical effect on the global dementia of patients. More long-term studies with larger sample sizes are needed to validate current findings.
Methods: We searched PubMed, Scopus, Cochrane Library, and Web of Science database on October 2020, with keywords: “Deep brain stimulation,” “Parkinson disease,” “dementia,” and “memory.” Reviews, abstracts, case presentations, and letters were excluded.
Results: In total, 491 studies were screened after removing the duplicates. The screening results yielded 81 articles to be screened for eligibility. Finally, 6 studies were included in this meta-analysis for synthesis. Overall, 800 patients were included in this meta-analysis, using the Mattis dementia rating scale (MDRS) and descriptive data from the articles extracted to assess global dementia.
Conclusion: Our results suggest that the STN-DBS group showed a larger cognitive decline than the patients receiving the best medical treatment (BMT). However, comparing STN-DBS with globus pallidus interna stimulation and pallidotomy could not demonstrate a significant statistical effect on the global dementia of patients. More long-term studies with larger sample sizes are needed to validate current findings.
نوع مطالعه: Review |
موضوع مقاله:
Clinical Neuroscience
دریافت: 1400/3/3 | پذیرش: 1401/7/5 | انتشار: 1402/12/11
دریافت: 1400/3/3 | پذیرش: 1401/7/5 | انتشار: 1402/12/11
| بازنشر اطلاعات | |
 |
این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است. |
