Volume 15, Issue 2 (March & April 2024)
BCN 2024, 15(2): 185-198 |
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Aliyari H, Sahraei H, Menhaj M B, Kazemi M, Vahidi B, Hosseinian S H. Environmental Effect of High-voltage Towers on the Cerebellum and Cognitive Impairments in the Monkey. BCN 2024; 15 (2) :185-198
URL: http://bcn.iums.ac.ir/article-1-2048-en.html
URL: http://bcn.iums.ac.ir/article-1-2048-en.html
Hamed Aliyari1 
, Hedayat Sahraei2 , Mohammad Bagher Menhaj3 , Masoomeh Kazemi2 , Behrooz Vahidi3 , Seyed Hossein Hosseinian * 3
, Hedayat Sahraei2 , Mohammad Bagher Menhaj3 , Masoomeh Kazemi2 , Behrooz Vahidi3 , Seyed Hossein Hosseinian * 3
1- Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, United States.
2- Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
3- Department of Electrical Engineering, School of Electrical, Computer & Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
2- Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
3- Department of Electrical Engineering, School of Electrical, Computer & Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
Abstract:
Introduction: Today, high-voltage (HV) lines create a pernicious environment for humans living or working in the vicinity and even under these lines. The male rhesus monkey is used to investigate the effects of fields produced by HV towers. This study examines the function and level of impact in rhesus monkeys’ brains from the cerebellum’s cognitive, biological, and structural perspective.
Methods: Two monkeys have been used, one as a control and the second as a test. The monkey under test was subjected to a simulated HV electrical field of 3 kV/m, 4 hours a day, for 1 month. Behavioral tests were performed using a device designed and built for this purpose. Concentration analysis of adrenocorticotropic hormones (ACTH) and inspection of glucocorticoid receptor gene’s (GR) expression were performed by the reverse transcription polymerase chain reaction method. Changes in cerebellar anatomy were examined with magnetic resonance imaging (MRI). All tests were performed before and after the study period and compared with the control monkey.
Results: Cognitive tests showed a significant reduction for the monkey exposed to the HV electrical field in the first week after imposition compared with the same time before. Also, the expression of the GR gene decreased, and the concentration of ACTH hormone in plasma increased. Surveying the level of cerebral MRI images did not show any difference, but hemorrhage was evident in a part of the cerebellum.
Conclusion: The tested monkey’s cognitive, biological, and MRI results showed a decrease in visual learning and memory indices.
Methods: Two monkeys have been used, one as a control and the second as a test. The monkey under test was subjected to a simulated HV electrical field of 3 kV/m, 4 hours a day, for 1 month. Behavioral tests were performed using a device designed and built for this purpose. Concentration analysis of adrenocorticotropic hormones (ACTH) and inspection of glucocorticoid receptor gene’s (GR) expression were performed by the reverse transcription polymerase chain reaction method. Changes in cerebellar anatomy were examined with magnetic resonance imaging (MRI). All tests were performed before and after the study period and compared with the control monkey.
Results: Cognitive tests showed a significant reduction for the monkey exposed to the HV electrical field in the first week after imposition compared with the same time before. Also, the expression of the GR gene decreased, and the concentration of ACTH hormone in plasma increased. Surveying the level of cerebral MRI images did not show any difference, but hemorrhage was evident in a part of the cerebellum.
Conclusion: The tested monkey’s cognitive, biological, and MRI results showed a decrease in visual learning and memory indices.
Type of Study: Original |
Subject:
Cognitive Neuroscience
Received: 2021/01/1 | Accepted: 2021/04/12 | Published: 2024/03/1
Received: 2021/01/1 | Accepted: 2021/04/12 | Published: 2024/03/1
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