Volume 12, Issue 3 (May & June 2021)
BCN 2021, 12(3): 361-372 |
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Rasoolijazi H, Norouzi Ofogh S, Ababzadeh S, Mehdizadeh M, Shabkhiz F. Comparing the Effects of Rosemary Extract and Treadmill Exercise on the Hippocampal Function and Antioxidant Capacity in Old Rats. BCN 2021; 12 (3) :361-372
URL: http://bcn.iums.ac.ir/article-1-1638-en.html
URL: http://bcn.iums.ac.ir/article-1-1638-en.html
Homa Rasoolijazi * 
1, Sattar Norouzi Ofogh2 , Shima Ababzadeh1 , Mehdi Mehdizadeh1 , Fatemeh Shabkhiz2
1, Sattar Norouzi Ofogh2 , Shima Ababzadeh1 , Mehdi Mehdizadeh1 , Fatemeh Shabkhiz2
1- Cellular & Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Neuroscience, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Neuroscience, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Abstract:
Introduction: A sequence of time-dependent changes can affect the brain’s functional capacity.
This study aimed at investigating the effects of Forced Aerobic Exercise (FAE) versus the Rosemary Extract (RE) on the learning abilities and oxidative stress modulation in rats.
Methods: Young and old rats received daily FAE and RE for 3 months. Using the Passive Avoidance (PA) test, we evaluated the learning and memory of the rats by Step-Through Latency (STL) score. We measured the Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx), Catalase (CATA), Malondialdehyde (MDA) enzymes levels, and Total Antioxidant Capacity (TAC) in the hippocampus
Results: FAE could significantly increase the STL score (P<0.001) among old rats similar to the rosemary extract consumption. The SOD, GPx, and CATA enzyme activities and the level of TAC significantly increased by the treatments (exercise: P<0.001 for SOD and TAC and P<0.05 for CATA, exercise/rosemary: P<0.001 for all enzymes, and rosemary: P<0.01 for SOD and TAC). Furthermore, the MDA level significantly decreased by the treatments (exercise and exercise/rosemary: P<0.001, rosemary: P<0.01). The partial Pearson test revealed the significant positive correlations between the score of STL (day 2) with the SOD (P<0.01) and TAC (P<0.05) levels and negative correlations between the MDA level and STL score in both days (P<0.05 for the first day and P<0.001 for the second day).
Conclusion: Similar to the rosemary extract, FAE could increase the working memory and antioxidants activity in old rats in 3 months.
This study aimed at investigating the effects of Forced Aerobic Exercise (FAE) versus the Rosemary Extract (RE) on the learning abilities and oxidative stress modulation in rats.
Methods: Young and old rats received daily FAE and RE for 3 months. Using the Passive Avoidance (PA) test, we evaluated the learning and memory of the rats by Step-Through Latency (STL) score. We measured the Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx), Catalase (CATA), Malondialdehyde (MDA) enzymes levels, and Total Antioxidant Capacity (TAC) in the hippocampus
Results: FAE could significantly increase the STL score (P<0.001) among old rats similar to the rosemary extract consumption. The SOD, GPx, and CATA enzyme activities and the level of TAC significantly increased by the treatments (exercise: P<0.001 for SOD and TAC and P<0.05 for CATA, exercise/rosemary: P<0.001 for all enzymes, and rosemary: P<0.01 for SOD and TAC). Furthermore, the MDA level significantly decreased by the treatments (exercise and exercise/rosemary: P<0.001, rosemary: P<0.01). The partial Pearson test revealed the significant positive correlations between the score of STL (day 2) with the SOD (P<0.01) and TAC (P<0.05) levels and negative correlations between the MDA level and STL score in both days (P<0.05 for the first day and P<0.001 for the second day).
Conclusion: Similar to the rosemary extract, FAE could increase the working memory and antioxidants activity in old rats in 3 months.
Type of Study: Original |
Subject:
Cellular and molecular Neuroscience
Received: 2019/10/26 | Accepted: 2020/04/7 | Published: 2021/05/1
Received: 2019/10/26 | Accepted: 2020/04/7 | Published: 2021/05/1
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