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1- Cellular & Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
2- Neuroscience Department, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
3- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran.
Background: A sequence of time-dependent changes can affect the brain's functional capacity.
Aims: This study aimed at investigating the effects of forced aerobic exercise (FAE) compared to the rosemary extract (RE) on learning abilities and oxidative stress modulation in rats.
Methods: Young and old rats received daily FAE and RE for 3 months. Step-through latency (STL) score, using the passive avoidance (PA) test, evaluated learning and memory. We measured the superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CATA), malondialdehyde (MDA) enzymes levels, and total antioxidant capacity (TAC) in the hippocampus.
Results: FAE and RE alone or in combination could significantly increase the STL score (p<0.001) among aged rat samples. The SOD, GPx and CATA enzyme activities and the level of TAC significantly increased by the treatments (exercise: p<0.001 for SOD & TAC and p<0.05 for CATA, exercise/rosemary: p<0.001 for all enzymes, and rosemary: p<0.01 for SOD and TAC). Furthermore, the MDA level significantly decreased by the treatments (exercise & exercise/rosemary: p<0.001, rosemary: p<0.01). Partial Pearson test revealed the positive significant correlations between the score of STL (day 2) with the SOD (p<0.01) and TAC (p<0.05) levels and negative correlations between the MDA level and STL score in both days (p<0.05 for the first day & p<0.001 for the second day).
Conclusion: Overall, exercise may exhibit more powerful changes than rosemary extract in aging.
Type of Study: Original | Subject: Cellular and molecular Neuroscience
Received: 2019/10/26 | Accepted: 2020/04/7 | Published: 2018/03/15

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