Volume 11, Issue 4 (July & August - Special Issue on Memory, Reward & Stress 2020)
BCN 2020, 11(4): 403-412 |
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Shafiei I, Ajdary M, Haghparast A, Mashhadiabbas F, Haghparast A. The Effect of Zinc and Vitamin D Nutrition on Reducing Morphine Side Effects and Development of Dental Anomalies in Rats Newborns. BCN 2020; 11 (4) :403-412
URL: http://bcn.iums.ac.ir/article-1-1507-en.html
URL: http://bcn.iums.ac.ir/article-1-1507-en.html
1- Department of Prosthodontics, Faculty of Dentistry, Kerman University of Medical Sciences, Kerman, Iran.
2- Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
3- School of Dentistry, International Branch of Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4- Oral and Maxillofacial Pathology Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran & Dental Research Center, Research institute of Dental School, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5- Department of Physiology, Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
3- School of Dentistry, International Branch of Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4- Oral and Maxillofacial Pathology Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran & Dental Research Center, Research institute of Dental School, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5- Department of Physiology, Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:
Introduction: The use of opioids such as morphine has anti-pain effects along with some side effects on body organs. Opioids such as morphine can be transferred from mother to child through the placenta and or breastfeeding. This study aimed to assess the effect of morphine on mineral content and histological changes of incisor teeth of rats born to morphine-addicted mothers.
Methods: In this experimental animal study, 24 pregnant rats were randomly divided into 6 groups of control, morphine, zinc, vitamin D, morphine plus zinc, and morphine plus vitamin D. After completion of the breastfeeding period, two babies were randomly selected among the newborns of each mother rat. Mineral content was analyzed using the Rontec device. The obtained data were analyzed by Newman-Keuls multiple comparisons test in Prism 5.
Results: Results showed a significant reduction in fluorine content in the experimental groups compared with the control group (P<0.05). The magnesium content in the experimental groups was significantly higher than that in the control group (P<0.05). Microscopic assessment of the slides showed a significantly less enamel maturation in the experimental groups compared with the control group (P<0.05).
Conclusion: Morphine use by mothers decreased the fluorine content of tooth structure and retarded the maturity of the enamel of infants.
Methods: In this experimental animal study, 24 pregnant rats were randomly divided into 6 groups of control, morphine, zinc, vitamin D, morphine plus zinc, and morphine plus vitamin D. After completion of the breastfeeding period, two babies were randomly selected among the newborns of each mother rat. Mineral content was analyzed using the Rontec device. The obtained data were analyzed by Newman-Keuls multiple comparisons test in Prism 5.
Results: Results showed a significant reduction in fluorine content in the experimental groups compared with the control group (P<0.05). The magnesium content in the experimental groups was significantly higher than that in the control group (P<0.05). Microscopic assessment of the slides showed a significantly less enamel maturation in the experimental groups compared with the control group (P<0.05).
Conclusion: Morphine use by mothers decreased the fluorine content of tooth structure and retarded the maturity of the enamel of infants.
Type of Study: Original |
Subject:
Behavioral Neuroscience
Received: 2019/05/17 | Accepted: 2019/08/13 | Published: 2020/07/1
Received: 2019/05/17 | Accepted: 2019/08/13 | Published: 2020/07/1
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