Accepted Articles                   Back to the articles list | Back to browse issues page


XML Print


1- Prosthetic Department, Dental School, Kerman University of Medical Sciences, Kerman, Iran
2- 2 Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
3- Oral and Maxillofacial Pathology Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:  
Introduction: The use of opioids such as morphine has anti-pain effects along with some side effects on body organs. Opioids such as morphine can be transferred from mother to child through the placenta and breastfeeding. This study aimed to assess the effect of morphine on mineral content and histological changes of incisor teeth of rats born to morphine-addicted mothers.
Methods: In this experimental animal study, 24 pregnant rats were randomly divided into six groups of control, morphine, zinc, vitamin D, morphine plus zinc and morphine plus vitamin D. After completion of the breastfeeding period, two babies were randomly selected among the newborns of each mother rat. Mineral content was analyzed using Rontec device. Data were analyzed using PRISM 5 and Newman-Keuls multiple comparisons test.
Results: Results showed a significant reduction in fluorine (F) content in the experimental groups compared to the control group (P<0.05). Magnesium content in the experimental groups was significantly higher than that in the control group (P<0.05). Microscopic assessment of the slides showed a significantly less enamel maturation in the experimental groups compared to the control group (P<0.05).
Conclusion: Morphine use by mothers decreased the fluorine content of tooth structure and retarded the maturity of enamel of infants.
 
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2019/05/17 | Accepted: 2019/08/13

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


© 2019 All Rights Reserved | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb