Volume 11, Issue 4 (July & August - Special Issue on Memory, Reward & Stress 2020)
BCN 2020, 11(4): 457-464 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Soleimani Asl S, Ghasemi Moravej F, Kowsari G, Farhadi M H, Pourhaydar B, Ghasemi Hamidabadi H et al . The Effects of 3,4-methylenedioxy- methamphetamine on Neurogenesis in the Hippocampus of Male Rats. BCN 2020; 11 (4) :457-464
URL: http://bcn.iums.ac.ir/article-1-1267-en.html
URL: http://bcn.iums.ac.ir/article-1-1267-en.html
Sara Soleimani Asl1 
, Fahimeh Ghasemi Moravej1 , Golshad Kowsari2 , Mohammad Hassan Farhadi3 , Bagher Pourhaydar4 , Hatef Ghasemi Hamidabadi5 , Mehdi Mehdizadeh * 6
, Fahimeh Ghasemi Moravej1 , Golshad Kowsari2 , Mohammad Hassan Farhadi3 , Bagher Pourhaydar4 , Hatef Ghasemi Hamidabadi5 , Mehdi Mehdizadeh * 6
1- Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran.
2- School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
3- Researcher of Subsance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
4- Department of Anatomy, Neurophysiology Research Center, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
5- Department of Anatomy and Cell Biology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
6- Department of Anatomy, Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
2- School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
3- Researcher of Subsance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
4- Department of Anatomy, Neurophysiology Research Center, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
5- Department of Anatomy and Cell Biology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
6- Department of Anatomy, Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Abstract:
Introduction: The administration of 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy causes memory impairment, whereas neurogenesis improves memory and learning. Hence, this study evaluated the effects of MDMA on neurogenesis in the hippocampus of male rats.
Methods: Adult male Wistar rats received Intraperitoneal (IP) injections of MDMA (10 mg/kg). We assessed nestin, sex-determining region Y-box 2 (Sox2), and NeuroD expressions according to the immunohistochemistry analyses.
Results: MDMA reduced the expressions of nestin, Sox2, and NeuroD compared with the control groups. The reduction in NeuroD expression was age-related.
Conclusion: MDMA possibly has negative effects on neurogenesis, which specifically results from impaired survival of newborn cells.
Methods: Adult male Wistar rats received Intraperitoneal (IP) injections of MDMA (10 mg/kg). We assessed nestin, sex-determining region Y-box 2 (Sox2), and NeuroD expressions according to the immunohistochemistry analyses.
Results: MDMA reduced the expressions of nestin, Sox2, and NeuroD compared with the control groups. The reduction in NeuroD expression was age-related.
Conclusion: MDMA possibly has negative effects on neurogenesis, which specifically results from impaired survival of newborn cells.
Keywords: N-Methyl-3, 4-methylenedioxyamphetamine, Hippocampus, Nestin, Sox2 Protein, NeuroD Protein
Type of Study: Original |
Subject:
Behavioral Neuroscience
Received: 2018/06/27 | Accepted: 2019/02/19 | Published: 2020/07/1
Received: 2018/06/27 | Accepted: 2019/02/19 | Published: 2020/07/1
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Copyright © The Author(s);
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Contact Information
