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1- 1- Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2- Researcher of Substance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences,Tehran,Iran
3- Urmia University of Medical Sciences, Faculty of Medicine, Neurophysiology Research Center, Department of Anatomy, Urmia, Iran
4- Department of Anatomy and Cell Biology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
5- Cellular and Molecular Research Center, Faculty of Advanced Technologies in Medicine, Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran
Abstract:  
Introduction: 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy administration causes memory impairment. Neurogenesis improves memory and learning. Hence, this study evaluated the effects of MDMA on neurogenesis in the hippocampus of male rats.
Methods: Adult male Wistar rats received intraperitoneal (IP) injections of 10 mg/kg MDMA. We assessed nestin, sex determining region Y-box 2 (Sox2), and NeuroD expressions according to immunohistochemistry (IHC) analyses.
Results: MDMA reduced expressions of nestin, Sox2, and NeuroD compared to the control groups. The reduction in NeuroD expression was age-related.
Conclusion: MDMA most likely has negative effects on neurogenesis, which specifically results from impaired survival of newborn cells.
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2018/06/27 | Accepted: 2019/02/19

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