Volume 9, Issue 2 (March & April 2018 2018)
BCN 2018, 9(2): 101-106 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Soleimani Asl S, Roointan A, Bergen H, Amiri S, Mardani P, Ashtari N, et al . Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran. BCN 2018; 9 (2) :101-106
URL: http://bcn.iums.ac.ir/article-1-872-en.html
URL: http://bcn.iums.ac.ir/article-1-872-en.html
Sara Soleimani Asl1 
, Amir Roointan2 , Hugo Bergen3 , Shayan Amiri4 , Parastoo Mardani5 , Niloufar Ashtari6 , Ronak Shabani6 , Mehdi Mehdizadeh * 6
, Amir Roointan2 , Hugo Bergen3 , Shayan Amiri4 , Parastoo Mardani5 , Niloufar Ashtari6 , Ronak Shabani6 , Mehdi Mehdizadeh * 6
1- Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
2- Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
3- Department of Human Anatomy and Cell Sciences, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
4- Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
5- Department of Biology, Faculty of Science, Tehran Branch, Payame Noor University, Tehran, Iran.
6- Cellular and Molecular Research Center, Department of Anatomy, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
3- Department of Human Anatomy and Cell Sciences, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
4- Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
5- Department of Biology, Faculty of Science, Tehran Branch, Payame Noor University, Tehran, Iran.
6- Cellular and Molecular Research Center, Department of Anatomy, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Abstract:
Introduction: Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence. In humans, A118G Single Nucleotide Polymorphisms (SNP) on μ-Opioid Receptor (MOR), 36 G>T in κ-Opioid Receptor (KOR), and T921C in the δ-Opioid Receptor (DOR) have been found to associate with substance dependence.
Methods: To investigate the association between opioid receptors gene polymorphism and heroin addiction, 100 control subjects with no history of opioid use, and 100 heroin addicts (50% males and 50% females) in Tehran (capital of Iran), were evaluated. A118G, 36 G>T, and T921C SNPs on the MOR, KOR, DOR genes, respectively, were genotyped by sequencing.
Results: We found no differences in either allele or genotype frequency for MOR, KOR and DOR genes SNPs between controls and subjects addicted to heroin.
Conclusion: The relationships among polymorphisms may be important in determining the risk profile for complex diseases such as addiction, but opioid addiction is a multifactorial syndrome which is partially hereditary and partially affected by the environment.
Keywords: μ-opioid receptor, κ-opioid receptor, δ-opioid receptor, Single nucleotide polymorphism, Heroin
Type of Study: Original |
Subject:
Behavioral Neuroscience
Received: 2016/11/23 | Accepted: 2017/09/26 | Published: 2018/03/3
Received: 2016/11/23 | Accepted: 2017/09/26 | Published: 2018/03/3
References
1. Bart, G., Heilig, M., LaForge, K., Pollak, L., Leal, S., Ott, J., et al. (2004). Substantial attributable risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central Sweden. Molecular Psychiatry, 9(6), 547-49. doi: 10.1038/sj.mp.4001504 [DOI:10.1038/sj.mp.4001504]
2. Beer, B., Erb, R., Pavlic, M., Ulmer, H., Giacomuzzi, S., Riemer, Y., & Oberacher, H. (2013). Association ofpolymorphisms in pharmacogenetic candidate genes (OPRD1, GAL, ABCB1, OPRM1) with opioid dependence in European population: A case-control study. PLoS ONE, 8(9), e75359. doi: 10.1371/journal.pone.0075359 [DOI:10.1371/journal.pone.0075359]
3. Bond, C., LaForge, K. S., Tian, M., Melia, D., Zhang, S., Borg, L., et al. (1998). Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: Possible implications for opiate addiction. Proceedings of the National Academy of Sciences, 95(16), 9608-13. doi: 10.1073/pnas.95.16.9608 [DOI:10.1073/pnas.95.16.9608]
4. Conner, B. T., Hellemann, G. S., Ritchie, T. L., & Noble, E. P. (2010). Genetic, personality, and environmental predictors of drug use in adolescents. Journal of Substance Abuse Treatment, 38(2), 178-190. doi: 10.1016/j.jsat.2009.07.004 [DOI:10.1016/j.jsat.2009.07.004]
5. Crist, R., Doyle, G., Kampman, K., & Berrettini, W. (2016). A delta-opioid receptor genetic variant is associated with abstinence prior to and during cocaine dependence treatment. Drug and Alcohol Dependence, 166, 268-71. doi: 10.1016/j.drugalcdep.2016.07.008 [DOI:10.1016/j.drugalcdep.2016.07.008]
6. Degenhardt, L., Whiteford, H. A., Ferrari, A. J., Baxter, A. J., Charlson, F. J., Hall, W. D., et al. (2013). Global burden of disease attributable to illicit drug use and dependence: findings from the Global Burden of Disease Study 2010. The Lancet, 382(9904), 1564-74. doi: 10.1016/s0140-6736(13)61530-5 [DOI:10.1016/S0140-6736(13)61530-5]
7. Franke, P., Nöthen, M. M., Wang, T., Neidt, H., Knapp, M., Lichtermann, D., et al. (1999). Human δ‐opioid receptor gene and susceptibility to heroin and alcohol dependence. American Journal of Medical Genetics, 88(5), 462-4. doi: 10.1002/(sici)1096-8628(19991015)88:5<462::aid-ajmg4>3.0.co;2-s
https://doi.org/10.1002/(SICI)1096-8628(19991015)88:5<462::AID-AJMG4>3.0.CO;2-S [DOI:10.1002/(SICI)1096-8628(19991015)88:53.0.CO;2-S]
8. Gelernter, J., & Kranzler, H. R. (2000). Variant detection at the δ opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence. Human Genetics, 107(1), 86-88. doi: 10.1007/s004390050016 [DOI:10.1007/s004390050016]
9. Gerra, G., Leonardi, C., Cortese, E., D'Amore, A., Lucchini, A., Strepparola, G., et al. (2007). Human kappa opioid receptor gene (OPRK1) polymorphism is associated with opiate addiction. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 144B(6), 771-5. doi: 10.1002/ajmg.b.30510 [DOI:10.1002/ajmg.b.30510]
10. Goldman, D., Oroszi, G., & Ducci, F. (2005). The genetics of addictions: uncovering the genes. Nature Reviews Genetics, 6(7), 521-32. doi: 10.1038/nrg1635 [DOI:10.1038/nrg1635]
11. Grösch, S., Niederberger, E., Lötsch, J., Skarke, C., & Geisslinger, G. (2001). A rapid screening method for a Single Nucleotide Polymorphism (SNP) in the human MOR gene. British Journal of Clinical Pharmacology, 52(6), 711-714. doi: 10.1046/j.0306-5251.2001.01504.x [DOI:10.1046/j.0306-5251.2001.01504.x]
12. Koch, T., Kroslak, T., Averbeck, M., Mayer, P., Schröder, H., Raulf, E., et al. (2000). Allelic variation S268P of the human μ-opioid receptor affects both desensitization and G protein coupling. Molecular Pharmacology, 58(2), 328-334. doi: 10.1124/mol.58.2.328 [DOI:10.1124/mol.58.2.328]
13. Kowarik, M. C., Einhäuser, J., Jochim, B., Büttner, A., Tölle, T. R., Riemenschneider, M., et al. (2012). Impact of the COMT Val 108/158 Met polymorphism on the mu-opioid receptor system in the human brain: Mu-opioid receptor, met-enkephalin and beta-endorphin expression. Neuroscience Letters, 506(2), 214-219. doi: 10.1016/j.neulet.2011.11.008 [DOI:10.1016/j.neulet.2011.11.008]
14. Kreek, M. J., Bart, G., Lilly, C., Laforge, K. S., & Nielsen, D. A. (2005). Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacological Reviews, 57(1), 1-26. doi: 10.1124/pr.57.1.1 [DOI:10.1124/pr.57.1.1]
15. Kumar, D., Chakraborty, J., & Das, S. (2012). Epistatic effects between variants of kappa-opioid receptor gene and A118G of mu-opioid receptor gene increase susceptibility to addiction in Indian population. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 36(2), 225-30. doi: 10.1016/j.pnpbp.2011.10.018 [DOI:10.1016/j.pnpbp.2011.10.018]
16. Li, M. D., & Burmeister, M. (2009). New insights into the genetics of addiction. Nature Reviews Genetics, 10(4), 225-31. doi: 10.1038/nrg2536 [DOI:10.1038/nrg2536]
17. Loh, E. W., Fann, C. S., Chang, Y. T., Chang, C. J., & Cheng, A. T. (2004). Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han. Alcoholism: Clinical and Experimental Research, 28(1), 15-19. doi: 10.1097/01.alc.0000106303.41755.b8 [DOI:10.1097/01.ALC.0000106303.41755.B8]
18. Majdzadeh, R., Feiz-Zadeh, A., Rajabpour, Z., Motevalian, A., Hosseini, M., Abdollahi, M., et al. (2009). Opium consumption and the risk of traffic injuries in regular users: A case-crossover study in an emergency department. Traffic Injury Prevention, 10(4), 325-29. doi: 10.1080/15389580902995380 [DOI:10.1080/15389580902995380]
19. Mayer, P., Rochlitz, H., Rauch, E., Rommelspacher, H., Hasse, H. E., Schmidt, S., et al. (1997). Association between a delta opioid receptor gene polymorphism and heroin dependence in man. NeuroReport, 8(11), 2547-50. doi: 10.1097/00001756-199707280-00025 [DOI:10.1097/00001756-199707280-00025]
20. Oslin, D. W., Berrettini, W., Kranzler, H. R., Pettinati, H., Gelernter, J., Volpicelli, J. R., et al. (2003). A functional polymorphism of the μ-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients. Neuropsychopharmacology, 28(8), 1546–1552. doi:10.1038/sj.npp.1300219 [DOI:10.1038/sj.npp.1300219]
21. Saito, M., Ehringer, M. A., Toth, R., Oros, M., Szakall, I., Sikela, J. M., et al. (2003). Variants of κ-opioid receptor gene and mRNA in alcohol-preferring and alcohol-avoiding mice. Alcohol, 29(1), 39-49. doi: 10.1016/s0741-8329(02)00322-1 [DOI:10.1016/S0741-8329(02)00322-1]
22. Shadnia, S., Soltaninejad, K., Heydari, K., Sasanian, G., & Abdollahi, M. (2008). Tramadol intoxication: A review of 114 cases. Human & experimental toxicology, 27(3), 201-5. [DOI:10.1177/0960327108090270] [PMID]
23. Sharafshah, A., Fazel, H., Albonaim, A., Omarmeli, V., Rezaei, S., Mirzajani, E., et al. (2017). Association of OPRD1 gene variants with opioid dependence in addicted male individuals undergoing methadone treatment in the north of Iran. Journal of Psychoactive Drugs, 49(3), 242–51. doi: 10.1080/02791072.2017.1290303 [DOI:10.1080/02791072.2017.1290303]
24. Soto, E. J. L., & Raingo, J. (2012). A118G mu opioid receptor polymorphism increases inhibitory effects on CaV2.2 channels. Neuroscience Letters, 523(2), 190-4. doi: 10.1016/j.neulet.2012.06.074 [DOI:10.1016/j.neulet.2012.06.074]
25. Stein, C. (2016). Opioid receptors. Annual Review of Medicine, 67(1), 433–51. doi: 10.1146/annurev-med-062613-093100 [DOI:10.1146/annurev-med-062613-093100]
26. Vadasz, C., Saito, M., Gyetvai, B., & Mikics, E. (2000). Scanning of five chromosomes for alcohol consumption loci. Alcohol, 22(1), 25-34. doi: 10.1016/s0741-8329(00)00098-7 [DOI:10.1016/S0741-8329(00)00098-7]
27. Wang, D., Quillan, J. M., Winans, K., Lucas, J. L., & Sadée, W. (2001). Single nucleotide polymorphisms in the human μ opioid receptor gene alter basal G protein coupling and calmodulin binding. Journal of Biological Chemistry, 276(37), 34624-30. doi: 10.1074/jbc.m104083200 [DOI:10.1074/jbc.M104083200]
28. Yuferov, V., Fussell, D., LaForge, K. S., Nielsen, D. A., Gordon, D., Ho, A., et al. (2004). Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction. Pharmacogenetics, 14(12), 793-804. doi: 10.1097/00008571-200412000-00002 [DOI:10.1097/00008571-200412000-00002]
29. Yuferov, V., Levran, O., Proudnikov, D., Nielsen, D. A., & Kreek, M. J. (2010). Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. Annals of the New York Academy of Sciences, 1187(1), 184-207. doi: 10.1111/j.1749-6632.2009.05275.x [DOI:10.1111/j.1749-6632.2009.05275.x]
30. Zhang, H., Kranzler, H., Yang, B., Luo, X., & Gelernter, J. (2007). The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. Molecular Psychiatry, 13(5), 531-43. doi: 10.1038/sj.mp.4002035 [DOI:10.1038/sj.mp.4002035]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Copyright © The Author(s);
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Contact Information
