Volume 9, Issue 2 (March & April 2018 2018)                   BCN 2018, 9(2): 129-134 | Back to browse issues page

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Moradi M, Saidijam M, Yadegarazari R, Jahangard L, Seifi M, Matinnia N et al . Genes Encoding GABA-β and HT1D Receptors in Bipolar I (Manic Phase) Patients. BCN 2018; 9 (2) :129-134
URL: http://bcn.iums.ac.ir/article-1-814-en.html
Genes Encoding GABA-β and HT1D Receptors in Bipolar I (Manic Phase) Patients
Mohammadreza Moradi1 , Massoud Saidijam1 , Reza Yadegarazari1 , Leila Jahangard2 , Maryam Seifi1 , Nasrin Matinnia3 , Ali Ghaleiha * 2
1- Molecular Medicine Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
2- Behavioral Disorders and Substance Abuse Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
3- Department of Nursing, Faculty of Science, Hamadan Branch, Islamic Azad University, Hamadan, Iran.
Abstract:  

Introduction: According to the cumulative evidence, genes encoding GABA receptors inhibit neurotransmitters in CNS and are intricately involved in the pathogenesis of mood disorders. Based on this hypothesis, these genes may be expressed in bipolar patients. As a result, we evaluated the gene expressions of GABA-β3 and HT1D receptors to assess their associations with bipolar mood disorder. 
Methods: In this study, 22 patients with bipolar I disorder (single manic episode) and 22 healthy individuals were enrolled. All participants were older than 15 years and had referred to Farshchian Hospital, Hamadan, Iran. They were diagnosed based on DSM IV–TR criteria and young mania rating scale in order to determine the severity of mania by a psychiatrist as bipolar Type 1 disorder in manic episode.  We evaluated the expression of GABA–β3 and HT1D receptor genes in peripheral blood mononuclear cells, using  real-time RT-PCR analysis.
Results: In our study, a reduction in the gene expression of GABA–β3 and HT1D receptors was observed in peripheral blood mononuclear cells of the patients with bipolar disorders compared to the healthy controls.
Conclusion: The results of this study supports the hypothesis that the gene expression for serotonin and GABA receptors can be employed  in elucidating the pathogenesis of bipolar disorders.

Keywords: GABA-β3, HT1D, Serotonin, Bipolar disorder, Gene expression
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Type of Study: Original | Subject: Clinical Neuroscience
Received: 2016/08/15 | Accepted: 2017/06/18 | Published: 2018/03/3
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