Volume 6, Issue 2 (Spring 2015 -- 2015)
BCN 2015, 6(2): 91-100 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Harandi S, Golchin L, Ansari M, Moradi A, Shabani M, Sheibani V. Antiamnesic Effects of Walnuts Consumption on Scopolamine- Induced Memory Impairments in Rats. BCN 2015; 6 (2) :91-100
URL: http://bcn.iums.ac.ir/article-1-523-en.html
URL: http://bcn.iums.ac.ir/article-1-523-en.html
Shaahin Harandi1 
, Leila Golchin1 , Mehdi Ansari2 , Alireza Moradi3 , Mohammad Shabani1 , Vahid Sheibani * 1
, Leila Golchin1 , Mehdi Ansari2 , Alireza Moradi3 , Mohammad Shabani1 , Vahid Sheibani * 1
1- Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
2- Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran
3- Neurobiomedical Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran
3- Neurobiomedical Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract:
Introduction: Alzheimer’s disease (AD) is an age-related neurodegenerative disease, which
impairs memory and cognitive function. Walnuts are a dietary source of polyphenols, antioxidants
and other compounds with health beneficial effects. These characteristic of walnuts make
them perfect candidates for evaluation of their possible effects on neurodegenerative diseases.
Therefore the present study was designed to investigate the effects of walnuts consumption (2%,
6% and 9% walnut diets) on memory enhancement and acetylcholinesterase (AChE) activity of
brain in scopolamine-induced amnesic rats.
Methods: Learning, memory and locomotor activity parameters were evaluated using Morris
water maze (MWM), passive avoidance and rotarod tests.
Results: Our results showed that consumption of walnuts at doses of 6% and 9% significantly
restored the scopolamine-induced memory impairments in the MWM and passive avoidance
tests. Moreover, the potential of walnuts to prevent scopolamine neurotoxicity was also reflected
by the decreased AChE activity in the whole brain in comparison with the scopolamine group.
Discussion: These results suggest that walnuts may be useful against memory impairment and
it may exert these anti-amnesic activities via inhibition of AChE activity in the brain. It would
be worthwhile to explore the potential of this nut and its active components in the management
of the AD.
Type of Study: Original |
Subject:
Cognitive Neuroscience
Received: 2014/08/9 | Accepted: 2015/01/10 | Published: 2015/04/1
Received: 2014/08/9 | Accepted: 2015/01/10 | Published: 2015/04/1
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Copyright © The Author(s);
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Contact Information
