Ecstasy-Induced Caspase Expression Alters Following Ginger Treatment

Soleimani Asl, Sara; Pourheydar, Bagher; Dabaghian, Fataneh; Nezhadi, Akram; Roointan, Amir; Mehdizadeh, Mehdi

Volume 4, Issue 4 (Autumn 2013 -- 2013) BCN 2013, 4(4): 329-333 | Back to browse issues page

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Soleimani Asl S, Pourheydar B, Dabaghian F, Nezhadi A, Roointan A, Mehdizadeh M. Ecstasy-Induced Caspase Expression Alters Following Ginger Treatment. BCN 2013; 4 (4) :329-333
URL: http://bcn.iums.ac.ir/article-1-437-en.html

Ecstasy-Induced Caspase Expression Alters Following Ginger Treatment

Sara Soleimani Asl

, Mehdi Mehdizadeh ^*

Abstract:

Introduction: Exposure to 3-4, methylenedioxymethamphetamine (MDMA) leads to cell death. Herein, we studied the protective effects of ginger on MDMA- induced apoptosis.

Methods:

15 Sprague dawley male rats were administrated with 0, 10 mg/kg MDMA, or MDMA along with 100mg/kg ginger, IP for 7 days. Brains were removed to study the caspase 3, 8, and 9 expressions in the hippocampus by RT-PCR. Data was analyzed by SPSS 16 software using the one-way ANOVA test. Results:
MDMA treatment resulted in a significant increase in caspase 3, 8, and 9 as compared to the sham group (p<0.001). Ginger administration however, appeared to significantly decrease the same (p<0.001). Discussion:
Our findings suggest that ginger consumption may lead to the improvement of MDMA-induced neurotoxicity.

Keywords: Apoptosis, Ginger, MDMA, Caspase

Full-Text [PDF 881 kb]

Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2013/11/8 | Accepted: 2014/08/26 | Published: 2014/08/26

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