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Elham Pishbin1 
, Zahra Ahamdi2 , Humain Baharvahdat3 , Shabnam Nirouman4 , Amirhosein Naseri5 , Elnaz Vafadar Moradi *1
, Zahra Ahamdi2 , Humain Baharvahdat3 , Shabnam Nirouman4 , Amirhosein Naseri5 , Elnaz Vafadar Moradi *1
1- Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
2- Student Research Committee, Faculty of Medicine, Shahrkord University of Medical Science, Shahrkord, Iran.
3- Department of Neurosurgery, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
4- Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5- Student Research Committee, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
2- Student Research Committee, Faculty of Medicine, Shahrkord University of Medical Science, Shahrkord, Iran.
3- Department of Neurosurgery, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
4- Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5- Student Research Committee, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
Abstract:
Introduction: Acute stroke represents a critical medical emergency that demands immediate intervention within the emergency department. The severity of this condition highlights the necessity for rapid medical action to mitigate potential cerebral damage and prevent long-term disabilities or mortality. In cases where ischemic stroke is confirmed, timely therapeutic interventions may include the administration of intravenous thrombolytic therapy (IVT) utilizing tissue plasminogen activator (tPA) or the implementation of mechanical thrombectomy.
Method: This cohort study targeted patients diagnosed with acute ischemic stroke who were considered suitable candidates for mechanical thrombectomy. Exclusion criteria included individuals with contraindications to the procedure, those unable to provide informed consent, and patients lacking legal representation for consent purposes. A comprehensive questionnaire was utilized to collect demographic information, medical histories, assessments of stroke severity, and precise documentation of symptom onset times. Furthermore, detailed information regarding the affected arterial pathway, Thrombolysis in Cerebral Infarction (TICI) grading, and patient outcomes at the three-month follow-up, as measured by the modified Rankin Scale, were systematically recorded.
Result: The cohort consisted of 169 patients, with a mean age of 57.85 years (ranging from 19 to 84 years). Among these participants, 76 individuals (44.7%) were male. The average score on the National Institutes of Health Stroke Scale (NIHSS) was determined to be 17.92, with scores ranging from 6 to 36. The average duration from symptom onset to the initiation of the thrombectomy procedure was recorded at 5.94 hours. A notable pattern of arterial involvement was predominantly observed in the middle cerebral artery (MCA).
Conclusion: The study used multivariate logistic regression analysis to elucidate the relationships between various factors and three-month outcomes on the modified Rankin Scale (MRS). After controlling for confounding variables, including the time interval from symptom onset and pre-existing medical conditions, the analysis revealed that advanced age and higher NIHSS scores were associated with an increased likelihood of unfavorable MRS outcomes.
Method: This cohort study targeted patients diagnosed with acute ischemic stroke who were considered suitable candidates for mechanical thrombectomy. Exclusion criteria included individuals with contraindications to the procedure, those unable to provide informed consent, and patients lacking legal representation for consent purposes. A comprehensive questionnaire was utilized to collect demographic information, medical histories, assessments of stroke severity, and precise documentation of symptom onset times. Furthermore, detailed information regarding the affected arterial pathway, Thrombolysis in Cerebral Infarction (TICI) grading, and patient outcomes at the three-month follow-up, as measured by the modified Rankin Scale, were systematically recorded.
Result: The cohort consisted of 169 patients, with a mean age of 57.85 years (ranging from 19 to 84 years). Among these participants, 76 individuals (44.7%) were male. The average score on the National Institutes of Health Stroke Scale (NIHSS) was determined to be 17.92, with scores ranging from 6 to 36. The average duration from symptom onset to the initiation of the thrombectomy procedure was recorded at 5.94 hours. A notable pattern of arterial involvement was predominantly observed in the middle cerebral artery (MCA).
Conclusion: The study used multivariate logistic regression analysis to elucidate the relationships between various factors and three-month outcomes on the modified Rankin Scale (MRS). After controlling for confounding variables, including the time interval from symptom onset and pre-existing medical conditions, the analysis revealed that advanced age and higher NIHSS scores were associated with an increased likelihood of unfavorable MRS outcomes.
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