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1- Department of Motor Behavior, Faculty of Sport Sciences, Alzahra University, Tehran, Iran
2- Department of Behavioral and Cognitive Science in Sport, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, Iran
3- Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Department of Behavioral and Cognitive Science in Sport, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, Iran
3- Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:
This study, building on earlier work on transgenerational influences on cognition, examined whether parental experience in a particular cognitive skill can enhance memory and learning processes in offspring. In particular, we asked whether maternal spatial training not only improves spatial memory in the next generation but also benefits short-term, long-term, and working memory. To address this, we tested groups of female offspring born to spatially trained or untrained mothers using the Morris Water Maze (MWM), Y-maze, and Novel Object Recognition (NOR) paradigms. The Results of implementing the present research protocol indicated that maternal MWM training enhances memory function and the learning process in female offspring when they are tested on the same task, an effect linked to enhanced hippocampal expression of SYT1 and BDNF, as well as increased ERK1/2 phosphorylation. In contrast, maternal spatial training had no significant impact on short- or long-term memory or on working memory more broadly, nor did it modify hippocampal SYT1, BDNF, or ERK1/2 phosphorylation levels in offspring following cognitive testing. Collectively, these results suggest that transgenerational impacts of maternal training in a cognitive task are task-specific and do not generalize to other untrained memory domains.
Keywords: Maternal spatial training, Transgenerational effects, Female offspring, Working memory, Short-term memory, Long-term memory
Type of Study: Original |
Subject:
Cellular and molecular Neuroscience
Received: 2025/02/25 | Accepted: 2025/05/11
Received: 2025/02/25 | Accepted: 2025/05/11
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