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1- Forestry Research Institute of Nigeria, Nigeria.
2- Department of Pharmacology & Therapeutics, Faculty of Medicine and Pharmacy, Kampala International University in Tanzania, United Republic of Tanzania, East Africa.
3- Department of Pharmacology & Therapeutics, University of Ibadan, Nigeria.
4- Department of Pharmacology & Therapeutics, University of Ilorin, Nigeria.
5- Department of Physiology, Ladoke Akintola University of Technology, Nigeria.
The use of benzodiazepines and selective serotonin reuptake inhibitors (SSRIs) to treat depression has been linked with serious adverse effects. Due to previous reports against anxiety and depression in traditional medicine, we designed this study to evaluate the effects of Justicia secunda's methanol extract (MLEJS) against anxiety and depression in mice. GC-MS (Gas Chromatography Mass Spectroscopy) phytochemical analysis of MLEJS was performed in this work to verify the different bioactive components. An acute oral toxicity study was performed via the Organization for Economic Co-operation and Development 423 (OECD) guideline. We investigate the antidepressant and anxiolytic effect of MLEJS (12.5, 25, and 50 mg/kg) using lipopolysaccharide LPS-induced depression and flumazenil/benzodiazepine GABA (gamma-amino-butyric acid) receptor interaction. The open field test (OFT), forced swimming test (FST), and tail suspension test (TST)  were performed to evaluate the depressive-like behavior in mice and hole-board, light and dark box, elevated plus maze, thiopental sodium, and rota-rod motor coordination test were used as a screening paradigm for the anxiolytic effect of MLEJS. The study's findings indicate that MLEJS had an anxiolytic-like effect by increasing exploration of the open arms and decreasing exploration of the closed arms in the elevated plus maze, light/dark, and hole-board tests. Additionally, lipopolysaccharide (LPS)-induced depressive-like behavior in mice was reversed by MLEJS (p<0.05). The significant (p<0.05) attenuation of pro-inflammatory mediators and suppression of oxido-nitrosative stress could be responsible for the observed effects. The results obtained in this study suggest that the MLEJS can offer an efficient therapeutic option against anxiety and depression concomitantly.
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2024/03/1 | Accepted: 2024/04/8

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