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1- Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Introduction:  The use of a 40 Hz white light emitting diode (WLED) has emerged as an alternative non-pharmacological and non-invasive approach to Alzheimerʼs disease (AD). Here we used behavioral tasks and measurements of some mitochondrial factors to address the therapeutic effects of 40 Hz WLED on psychiatric symptoms (PS) and the contribution of mitochondrial factors in the early stages of sporadic AD in rats.
Materials and methods: The AD model was induced via intracerebroventricular (ICV) injection of streptozotocin in male wistar rat. After recovering (7 days) from stereotaxic surgery, 40-Hz WLED exposure was performed for 7 consecutive days lasting 15 min/day. Behavioral (elevated plus maze, force swim, and social interaction test), enzymatic, and molecular assays were conducted after 24 h of the last 40-Hz WLED exposure.
Results: Behavioral tasks revealed that 40-Hz WLED exposure in stz-induced toxicity rats, lowered anxiety and depression and increased social interaction. furthermore the 40-Hz WLED therapy in stz-induced toxicity rats, led to increased catalase activity in the amygdala, decreased the activity of monoamine oxidases A and B in the whole brain, and increased mitochondrial DNA in the hippocampus.
Conclusion: The current study explains that 40-Hz WLED therapy in the early stages of sporadic AD improved psychiatric symptoms and biomarkers.  also it seems that there is a potential relationship between alterations in mitochondrial markers in certain brain regions and PS.
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2024/01/8 | Accepted: 2024/01/16

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