Accepted Articles                   Back to the articles list | Back to browse issues page

XML Print

1- Neuroscience Research Center, Department of Anatomy, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
2- Neuroscience Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Background: Glutamate plays a major role in synaptic plasticity that is important for learning and memory. Astrocyte is important neuroglia, involves in the neuroinflammation and plays a key role in maintaining glutamine/glutamate homeostasis. As astrocytes provide a vital support to neurons in pathological conditions. Hence, in this study, we aimed to evaluate the effect of hippocampal astrocytes ablation induced by microinjection of L-α-aminoadipic acid (L-α-AAA) on memory, anxiety and the density of GFAP-ir astrocytes in the hippocampus.
Methods: Adult male Wistar rats were randomly assigned to control, vehicle, and experimental group. L-α-AAA was injected into the hippocampal CA1 subfield for 3 days. Memory was evaluated by inhibitory passive avoidance test and anxiety-related behavior was assessed by elevated plus maze apparatus. Hippocampal sections were immunostained for GFAP and the density of GFAP-ir astrocytes were counted.
Results: Microinjection of L-α-AAA into the CA1 subfield of the hippocampus significantly decreased the step-through latency time in passive avoidance test and significantly decreased time spent in open arm and increased time spent in closed arm in elevated plus maze test. Also, administration of L-α-AAA significantly declined the density of GFAP-ir astrocytes in the hippocampus.
Conclusion: Inhibition of astrocytes impaired the memory and increased the anxiety-like behavior in male rats. Hence, the current study confirmed hippocampal astrocyte’s key role in memory and anxiety-like behavior which can be considered in future therapeutic strategies.
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2023/09/6 | Accepted: 2024/04/8

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb