Volume 15, Issue 1 (January & February 2024)                   BCN 2024, 15(1): 27-36 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ahmadi-Soleimani S M, Salmanzadeh H, Azizi H. Experimental Evidence on Age-related Differential Outcomes Associated With Substance Abuse. BCN 2024; 15 (1) :27-36
URL: http://bcn.iums.ac.ir/article-1-2760-en.html
1- Departments of Physiology, Neuroscience Research Center, School of Medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
2- TJ Long School of Pharmacy, University of the Pacific, Stockton, The United States.
3- Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Growing evidence indicates that adolescent substance abuse is now an alarming concern that imposes a considerable socio-economic burden on societies. On the other hand, numerous studies have shown that due to specific neurophysiological features, the brain is more vulnerable to the adverse effects of psychoactive drugs at an early age. Unfortunately, these negative effects are not limited to the period of drug use, but can persistently affect the brain’s responsiveness to future exposures to the same or other types of drug. For researchers to develop pharmacological strategies for managing substance abuse disorders, they need to gain a deep understanding of the differences in behavioral outcomes associated with each type of drug across different age groups. The present study was conducted to review the experimental evidence revealing the mentioned differential effects with an emphasis on common drugs of abuse, including cocaine, nicotine, cannabis, and opioids. Although the cellular mechanisms underlying age-related effects have not been exclusively addressed for each drug, the most recent results are presented and discussed. Future studies are required to focus on these mechanisms and reveal how molecular changes during brain development can result in differential responses to drugs at the behavioral level. 
Type of Study: Review | Subject: Behavioral Neuroscience
Received: 2023/07/25 | Accepted: 2023/08/9 | Published: 2024/01/1

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb