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Mohammad Amin Habibi1 
, Ali Anjomshoa1 , Mohsen Sadeghi-Naini1 , Zahra Ghodsi1 , Samuel B. Kankam1 , Erfan Razavi1 , Armin Aryannejad1 , Seyed Mohammad Piri1 , Akam Ramezani1 , Rasha Atlasi1 , Kawthar Mohamed1 , Sina Shool1 , Meysam Kaveh1 , Akbar Fotouhi1 , Arman Zeinaddini1 , James S. Harrop2 , Alex R. Vaccaro3 , Michael G. Fehlings4 , Vafa Rahimi-Movaghar *1
, Ali Anjomshoa1 , Mohsen Sadeghi-Naini1 , Zahra Ghodsi1 , Samuel B. Kankam1 , Erfan Razavi1 , Armin Aryannejad1 , Seyed Mohammad Piri1 , Akam Ramezani1 , Rasha Atlasi1 , Kawthar Mohamed1 , Sina Shool1 , Meysam Kaveh1 , Akbar Fotouhi1 , Arman Zeinaddini1 , James S. Harrop2 , Alex R. Vaccaro3 , Michael G. Fehlings4 , Vafa Rahimi-Movaghar *1
1- Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Neurological and Orthopedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
3- Department of Orthopedics and Neurosurgery, Thomas Jefferson University and the Rothman Institute, Philadelphia, Pennsylvania, USA
4- Division of Neurosurgery, University of Toronto, University of Toronto, Toronto, Canada
2- Department of Neurological and Orthopedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
3- Department of Orthopedics and Neurosurgery, Thomas Jefferson University and the Rothman Institute, Philadelphia, Pennsylvania, USA
4- Division of Neurosurgery, University of Toronto, University of Toronto, Toronto, Canada
Abstract:
Background/Objectives: Chondroitinase ABC (ChABC) has been known as a potential treatment option for spinal cord injury (SCI). We aim to identify and evaluate the histopathological effects of intrathecal ChABC administration in SCI rat models.
Methods: We searched PubMed/MEDLINE, Scopus, Web of Science, Embase, and Cochrane Library for studies published from the inception of each database until 22 November 2022.
Results: Of 3857 screened citations, 17 studies met eligibility criteria and were entered into the qualitative analysis. Sixteen studies were of high quality and one study was of medium quality. The Four main types of rats used in studies included Sprague Dawley, Wistar, Lister hooded and Long-Evans rats, respectively. ChABC treatment phases were considered acute (within 24 hours after injury), sub-acute (five or seven days after injury), or chronic (four or six weeks after injury). Accordingly, ChABC administration in the acute phase of injury significantly reduced cyst formation and promoted tissue preservation and sensory neuron plasticity. Regardless of the treatment phase, ChABC administration significantly promoted serotonergic and corticospinal fiber plasticity. Nine of the 14 studies that reported on functional outcomes found that ChABC administration either alone or combined with other treatments including rehabilitation improved motor functions.
Conclusions: The specification of anatomical changes for ChABC treatment can be used to explain functional improvements that have been reported for ChABC use in SCI. The limited studies on more clinically relevant contusion and compression injury models warrant further studies on these injury models and alternate treatment phases.
Methods: We searched PubMed/MEDLINE, Scopus, Web of Science, Embase, and Cochrane Library for studies published from the inception of each database until 22 November 2022.
Results: Of 3857 screened citations, 17 studies met eligibility criteria and were entered into the qualitative analysis. Sixteen studies were of high quality and one study was of medium quality. The Four main types of rats used in studies included Sprague Dawley, Wistar, Lister hooded and Long-Evans rats, respectively. ChABC treatment phases were considered acute (within 24 hours after injury), sub-acute (five or seven days after injury), or chronic (four or six weeks after injury). Accordingly, ChABC administration in the acute phase of injury significantly reduced cyst formation and promoted tissue preservation and sensory neuron plasticity. Regardless of the treatment phase, ChABC administration significantly promoted serotonergic and corticospinal fiber plasticity. Nine of the 14 studies that reported on functional outcomes found that ChABC administration either alone or combined with other treatments including rehabilitation improved motor functions.
Conclusions: The specification of anatomical changes for ChABC treatment can be used to explain functional improvements that have been reported for ChABC use in SCI. The limited studies on more clinically relevant contusion and compression injury models warrant further studies on these injury models and alternate treatment phases.
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