Volume 17, Issue 1 (January & February 2026)
BCN 2026, 17(1): 1-24 |
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Habibi M A, Anjomshoa A, Sadeghi-Naini M, Ghodsi Z, Berchi Kankam S, Razavi E, et al et al . Histopathological Effects of the Intrathecal Chondroitinase ABC Administration in Spinal Cord Injured Rats: A Systematic Review. BCN 2026; 17 (1) :1-24
URL: http://bcn.iums.ac.ir/article-1-2744-en.html
URL: http://bcn.iums.ac.ir/article-1-2744-en.html
Mohammad Amin Habibi1 
, Ali Anjomshoa2 , Mohsen Sadeghi-Naini3 , Zahra Ghodsi4 , Samuel Berchi Kankam5 , Erfan Razavi6 , Armin Aryannejad7 , Seyed Mohammad Piri1 , Akam Ramezani6 , Rasha Atlasi8 , Kawthar Mohamed9 , Sina Shool10 , Meysam Kaveh6 , Akbar Fotouhi11 , Arman Zeinaddini1 , James S. Harrop12 , Alex R. Vaccaro13 , Michael G. Fehlings14 , Vafa Rahimi-Movaghar *15
, Ali Anjomshoa2 , Mohsen Sadeghi-Naini3 , Zahra Ghodsi4 , Samuel Berchi Kankam5 , Erfan Razavi6 , Armin Aryannejad7 , Seyed Mohammad Piri1 , Akam Ramezani6 , Rasha Atlasi8 , Kawthar Mohamed9 , Sina Shool10 , Meysam Kaveh6 , Akbar Fotouhi11 , Arman Zeinaddini1 , James S. Harrop12 , Alex R. Vaccaro13 , Michael G. Fehlings14 , Vafa Rahimi-Movaghar *15
1- Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
2- Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. & Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran. & Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
3- Department of Neurosurgery, School of Medicine, Lorestan University of Medical Sciences, Khorram Abad, Iran.
4- Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. & Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
5- Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. & School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
6- Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
7- Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
8- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
9- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. & Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Manama, Bahrain.
10- School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
11- Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
12- Department of Neurological and Orthopedic Surgery, Thomas Jefferson University, Philadelphia, United States.
13- Department of Orthopedics and Neurosurgery, Thomas Jefferson University, Philadelphia, United States. & Rothman Institute, Philadelphia, United States.
14- Spinal Program, Toronto Western Hospital, University Health Network, Toronto, Canada. & Division of Neurosurgery, University of Toronto, Toronto, Canada.
15- Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. & Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. & Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. & Universal Scientific Education and Research Network (USERN), Tehran, Iran. & Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
2- Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. & Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran. & Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
3- Department of Neurosurgery, School of Medicine, Lorestan University of Medical Sciences, Khorram Abad, Iran.
4- Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. & Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
5- Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. & School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
6- Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
7- Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
8- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
9- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. & Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Manama, Bahrain.
10- School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
11- Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
12- Department of Neurological and Orthopedic Surgery, Thomas Jefferson University, Philadelphia, United States.
13- Department of Orthopedics and Neurosurgery, Thomas Jefferson University, Philadelphia, United States. & Rothman Institute, Philadelphia, United States.
14- Spinal Program, Toronto Western Hospital, University Health Network, Toronto, Canada. & Division of Neurosurgery, University of Toronto, Toronto, Canada.
15- Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. & Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. & Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. & Universal Scientific Education and Research Network (USERN), Tehran, Iran. & Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
Abstract:
Introduction: Chondroitinase ABC (ChABC) has been considered a potential treatment for spinal cord injury (SCI). We aim to identify and evaluate the histopathological effects of intrathecal ChABC administration in SCI rat models.
Methods: We searched PubMed/MEDLINE, Scopus, Web of Science, Embase, and Cochrane Library for studies published from the inception of each database until November 22, 2022.
Results: Of 3857 screened citations, 17 studies met eligibility criteria and were entered into the qualitative analysis. Sixteen studies were of high quality, and one study was of medium quality. The four main rat strains used in studies were Sprague-Dawley, Wistar, Lister hooded, and Long-Evans. ChABC treatment phases were considered acute (within 24 hours after injury), subacute (5 or 7 days after injury), or chronic (4 or 6 weeks after injury). Accordingly, ChABC administration in the acute phase of injury significantly reduced cyst formation and promoted tissue preservation and sensory neuron plasticity. Regardless of the treatment phase, ChABC administration significantly promoted serotonergic and corticospinal fiber plasticity. Nine of the 14 studies reporting on functional outcomes found that ChABC administration, alone or in combination with other treatments, including rehabilitation, improved motor function.
Conclusion: The specification of anatomical changes associated with ChABC treatment can explain the functional improvements reported with its use in SCI. The limited studies on more clinically relevant contusion and compression injury models warrant further investigation of these models and alternative treatment phases.
Methods: We searched PubMed/MEDLINE, Scopus, Web of Science, Embase, and Cochrane Library for studies published from the inception of each database until November 22, 2022.
Results: Of 3857 screened citations, 17 studies met eligibility criteria and were entered into the qualitative analysis. Sixteen studies were of high quality, and one study was of medium quality. The four main rat strains used in studies were Sprague-Dawley, Wistar, Lister hooded, and Long-Evans. ChABC treatment phases were considered acute (within 24 hours after injury), subacute (5 or 7 days after injury), or chronic (4 or 6 weeks after injury). Accordingly, ChABC administration in the acute phase of injury significantly reduced cyst formation and promoted tissue preservation and sensory neuron plasticity. Regardless of the treatment phase, ChABC administration significantly promoted serotonergic and corticospinal fiber plasticity. Nine of the 14 studies reporting on functional outcomes found that ChABC administration, alone or in combination with other treatments, including rehabilitation, improved motor function.
Conclusion: The specification of anatomical changes associated with ChABC treatment can explain the functional improvements reported with its use in SCI. The limited studies on more clinically relevant contusion and compression injury models warrant further investigation of these models and alternative treatment phases.
Type of Study: Review |
Subject:
Clinical Neuroscience
Received: 2025/07/14 | Accepted: 2025/08/12 | Published: 2026/01/1
Received: 2025/07/14 | Accepted: 2025/08/12 | Published: 2026/01/1
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