Accepted Articles                   Back to the articles list | Back to browse issues page

XML Print

1- Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Emergency Medicine, NYC Health & Hospitals, Coney Island, New York, USA.
Background: The present systematic review and meta-analysis was designed to investigate platelet-rich plasma as an effective treatment for spinal cord injury in animal models.
Method: An extensive literature search was conducted using electronic databases. The included studies were summarized based on the investigated outcomes, including functional recovery and cavity size. Data were recorded as mean and standard deviation. The relationship between variables and the outcomes was investigated based on the “meta” command in the STATA 17.0 statistical program.
Results: In total, 9 articles were included in the present meta-analysis. Pooled data analysis showed that the administration of platelet-rich plasma significantly improved the motor function of animals (SMD= 1.5; 95%CI: 0.9 - 2.1; p< 0.0001). In subgroup analysis based on the severity of the injury, platelet-rich plasma administration significantly improved the motor function of animals in both moderate (SMD= 2.59l 95%CI: 1.59 - 3.59; p< 0.0001; I2= 30.22%) and severe injuries (SMD= 1.22; 95%CI: 0.64 - 1.79; p< 0.0001; I2= 56.35%); However, the recovery of function was significantly more in animals with moderate spinal cord injury (Meta-regression coefficient= -1.36; 95%CI: -2.68 - -0.09; p= 0.035). In the assessment of cavity size, pooled data analysis showed that PRP administration results in a significant reduction in cavity size (SMD= -2.2; 95%CI: -3.44 - -0.95; p< 0.0001).
Discussion: This meta-analysis showed that the administration of platelet-rich plasma can significantly improve motor function and reduce the cavity size in animals with moderate to severe spinal cord injuries.
Type of Study: Review | Subject: Cellular and molecular Neuroscience
Received: 2022/12/29 | Accepted: 2023/07/2

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb