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1- Department of Psychiatry, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
2- Department of Educational Sciences, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
3- Department of Clinical Psychology, Social Determinants of Health Research Center, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Background: This study aims to assess and compare the effects of low-frequency (LF) cognitive-behavioral therapy (CBT) and repetitive transcranial magnetic stimulation (rTMS) on symptoms and cognitive flexibility of adults with OCD.
Methods: This is a randomized clinical trial conducted on 24 people with OCD in Zanjan, Iran in two groups of CBT (n=12) and rTMS (n=12). The CBT with exposure and response prevention was presented at 20 sessions. The 1-Hz rTMS was delivered at 100 of resting MT using an 8-shaped coil over the right dorsolateral prefrontal cortex (F4) for 2 weeks at 10 sessions. They completed the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the Cognitive Flexibility Inventory before, immediately, and one month after the intervention. Collected data were analyzed in SPSS v.22 software.
Results: Results showed a significant difference between the two groups in the severity of OCD symptoms (obsessions and compulsions) immediately after intervention (p<0.001), where higher reductions were observed in the CBT group. There was no significant difference between the two groups in cognitive flexibility (p>0.05). No significant difference was found between the groups in any study variables one month after interventions.
Conclusion: There is a significant difference between CBT and LF rTMS techniques in reducing the severity of OCD symptoms, while there is no difference between them in improving cognitive flexibility of patients with OCD.
Type of Study: Original | Subject: Clinical Neuroscience
Received: 2022/12/4 | Accepted: 2023/08/16

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