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1- Institute for Cognitive Science Studies (ICSS), Tehran, Iran.
2- Clinical Psychology Department, Kharazmi University, Tehran, Iran.
3- Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Background: interventions using ‘hybrid’ remediation/ compensatory cognitive interventions may be beneficial to improving socio- cognitive functioning of children with autism spectrum disorder (ASD). Previous studies have showed neurocognitive impairments in executive function (EF) and theory of mind (TOM) are specifically associated with ASD.
Aim: the primary aim of the study is to determine the impact of the remediation and compensatory cognitive intervention on executive functions and theory of mind abilities. The secondary aim is to evaluate TOM and EF behavioral domains as result of the remediation and compensatory cognitive intervention.
Methods/ Design: 75 children aged 4 to 7 diagnosed high- functioning autism and their parents will be recruited to this double-blind, multicenter, multi-arm randomized controlled trial. The primary outcome is executive functions and theory of mind as measured by the shape school, shape span test, TOM scale, TOM story books, TOM assessment checklist, and EFs assessment checklist. The secondary outcome is EFs and TOM behavioral domains as measured by TOM behavior checklist, and brief-preschool version at baseline (T0), post- treatment (T1), one-month follow-up (T2) and three-month follow-up (T3). Primary and secondary outcomes will be analyzed using repeated mesesure Analysis of Variance (ANOVA) and mixed model.
Discussion: the study will assess whether the cognitive intervention program effect not only on neuropsychological functioning of children with ASD but also on daily functioning. If the current trial shows that either the remediation approach and compensatory approach, or both are effective in improving socio-cognitive functioning, the trial would reveal a ‘hybrid’ remediation/ compensatory approach.
Type of Study: Methodological Notes | Subject: Clinical Neuroscience
Received: 2022/12/3 | Accepted: 2023/03/4

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