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1- Department of Psychology, University of Tehran, Tehran, Iran
2- Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
3- Department of Psychiatry, Psychosis Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
4- School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran
5- Shahid Beheshti University, Tehran, Iran
6- Mental Health Research Center, Psychosocial Health Research Institute (PHRI), Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Brain and Cognition Clinic, Institute for Cognitive Sciences Studies, Tehran, Iran
Abstract:  
Introduction: Obsessive-compulsive disorder (OCD) is a disabling mental condition. Many studies have shown that OCD patients have cognitive deficits in various aspects of their cognition which are a worsening factor of the severity of symptoms, potential endophenotype, a predictor of insight and prognostic marker of OCD as well. We designed this systematic review to evaluate clinical efficacy of cognitive rehabilitation in cognitive deficits and symptom severity of patients with OCD, in accordance with PRISMA guidelines.
Method: We searched Pubmed, Scopus, Sciencedirect, Google scholar, and Cochrane library in this study with the MeSH terms and keywords of ‘cognitive rehabilitation’ and ‘obsessive-compulsive disorder’. The database searches identified 200 records of interest initially which 105 duplications removed from them. From 95 remaining studies, six articles were eligible for the study and met the inclusion criteria. The six articles describe individual RCT studies representing a wide variety of study designs.
Results: These six included studies investigate the efficacy of “organizational training”, “cognitive remediation”, “attention splitting” and “goal management training” on cognitive impairments and symptom severity of OCD patients.
There are a small number of studies, with different designs and some concerning biases which have investigated the efficacy of cognitive rehabilitation in OCD patients and they have inconsistent results about effect of cognitive rehabilitation on OCD symptom severity or cognitive deficits.
Conclusion: According to the results, we cannot conclude about the efficacy of cognitive rehabilitation in adults with OCD. On account of the importance of cognitive deficits in OCD patients, it is necessary to design and conduct standard trials to investigate the role of cognitive rehabilitation on these impairments.
Type of Study: Review | Subject: Cellular and molecular Neuroscience
Received: 2022/10/16 | Accepted: 2022/11/12

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