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1- Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
2- Institute for Cognitive Science Studies, Pardis, Tehran, Iran.
Introduction: It is not rare that an OCD patient does not response desirably to first chosen medication, and it may last up to one year to find the best treatment. According to the consequences of failed antidepressant therapy for OCD, any factor that can predict responsiveness, would be of high importance. We investigated potential predictive value of quantitative electroencephalography in the responsiveness of OCD patients to Fluvoxamine.
Methods: We included 40 medication free non-depressed OCD patients, assessed before intervention and six weeks after. Five minutes of opened eyes and closed eyes QEEG records were taken. The relative power of each frequency band was calculated for all electrodes. The patients received Fluvoxamine, 150-300 mg per day. We compared the waves between responders and non-responders, by univariate analyses and multivariate logistic regression.
Results: Responsiveness was correlated with normal relative powers in FP1, FP2, FZ and F3 and increased relative power in O1 in closed eyes condition and increased relative power of alpha in O1 and O2 and normal relative powers in FP1 and FP2 with open eyes. Unresponsiveness was correlated with increased theta in FP2, FZ and F3 and unincreased alpha in O1 with closed eyes and increased alpha in the O1 and O2 in opened eyes condition.
Conclusion: The electroencephalographic waves of medial-frontal area and occipital areas can be biomarkers to predict responsiveness to treatment with Fluvoxamine.
Type of Study: Original | Subject: Cognitive Neuroscience
Received: 2022/08/20 | Accepted: 2023/09/4

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