Ahmadirad N, Bakhtiarzadeh F, Zare M, Ghasemi Z, Sadeghin A, Dehghan S et al . Neurostimulation as a Putative Method for Treatment of Drug-Resistant Epilepsy in Patient and Animal Models of Epilepsy. BCN 2023; 14 (1)
URL:
http://bcn.iums.ac.ir/article-1-2507-en.html
1- Associate Research Scientist Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
2- Researcher Tarbiat Modares University, Department of Physiology, Tehran, Iran.
3- Researcher Stem cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran.
4- Associate Research Scientist - Lunenfeld-Tanenbaum Research Institute, Toronto, Canada
5- Eye Research Center, the Five Senses Institute, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
6- Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Abstract:
A patient with epilepsy was shown to have neurobiological, psychological, cognitive, and social issues as a result of recurring seizures, which is regarded to be a chronic brain disease.However, despite numerous drug treatments, approximately, 30–40% of all patients are resistant to antiepileptic drugs. Therefore, newer therapeutic modalities are introduced into clinical practice in which involve neurostimulation and direct stimulation of the brain. Hence, we review published literature regarding the vagus nerve stimulation, trigeminal nerve stimulation, applying responsive stimulation systems and DBS in animals and epileptic patient with an emphasis on drug-resistant epilepsy.
Type of Study:
Review |
Subject:
Behavioral Neuroscience Received: 2022/07/6 | Accepted: 2022/10/18 | Published: 2023/01/12