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1- Department of Biochemistry, King George's Medical University, Lucknow, India.
2- Department of Biotechnology, BBAU, Lucknow, India.
3- Department of Zoology, University of Lucknow, Lucknow, India.
Stress disorders have multidimentional effect on us. The way we respond to these situations is different, which depends upon our individual difference and our sex or gender. Reports suggests that females are more susceptible to stress disorders as compared to the male person with same age group. Serotonin receptor system is an important mechanism involved in regulation of stress and anxiety in male and female both individuals. Current study incorporates rodent model to study sex-based role of serotonin receptors under chronic restrained stress condition. A chronic restrained stress protocol was used to assign the stress difference between male and female Sprague-Dawley rats. The molecular identification was done using quantitative real-time PCR and immunohistochemistry for serotonin 5HT-1B receptor in rat brain.
Interestingly, 5HT-1B receptor which is one of the most important serotonin receptors, exhibited a sex dependent difference for stress response in male and female rats. Most importantly the trio partners (amygdala, hippocampus and prefrontal cortex), exhibited a region-specific sex dependent difference in 5HT-1B receptor expression which was correlated with the difference in the level of stress response. This biased function of serotonin 5HT-1B receptor might be the reason why females face more stress than male individual.
Overall, the result exhibited a sex dependent difference for stress condition in male and female rats, which was correlated with the spatial expression of serotonin 5HT-1B receptor in brain.
Type of Study: Original | Subject: Cellular and molecular Neuroscience
Received: 2022/05/15 | Accepted: 2024/04/13

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