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Elahe Habibitabar1 
, Shima Khanverdiloo1 , Mona Doostizadeh1 , Leila Jahangard1 , Jamshid Karimi1 , Gholamreza Shafiee * 1
, Shima Khanverdiloo1 , Mona Doostizadeh1 , Leila Jahangard1 , Jamshid Karimi1 , Gholamreza Shafiee * 1
1- Medicine Student, Medicine school, Hamadan University of Medical Sciences, Hamadan, Iran.
Abstract:
Major depressive disorder (MDD) is ne of the common psychiatric disorders that is characterized by abnormal neurobiological responses. Proprotein convertase subtilisin/kexin 9 (PCSK9) have a important role in cholesterol homeostasis. This study was aimed to investigate PCSK9 level and oxidative stress with MDD disease.The study included 30 with MDD and 30 healthy controls. The. Blood was collected in sterile tubes and the serum PCSK9 concentration, SOD and GPx activity were determined by ELISA kits. TAC, TOS, MDA and copper concentration were determined manually.There was a significant increase in PCSK9 level in the patient group (p<0.05). ROC curve had sensitivity of 57% and specificity of 52% and 0.928 (95% CI, 0.86-0.996) for PCSK9, in the patient group (p <0.001). It was found that MDA (p = 0.036) level was higher in MDD group, but TAC (p = 0.445) level, SOD (p = 0.148), GPx (p = 0.019) activities and copper concentration were lower in the patient group in compare with the control group.In conclusion, this study results confirm the relationship of oxidative stress and major depressive disorder and also suggest a link between PCSK9 and MDD disease.
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