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Elham Maraghi1 
, Ali Reza Safarpour2 , Maryam Hajmohammadi3 , Ali Akbar Oroojan4 , Amal Saki Malehi1 , Hadis Ashrafizadeh * 5
, Ali Reza Safarpour2 , Maryam Hajmohammadi3 , Ali Akbar Oroojan4 , Amal Saki Malehi1 , Hadis Ashrafizadeh * 5
1- Assistant Professor of Biostatistics, Department of Biostatistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran.
2- Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
3- MSc student of Biostatistics, Student Research Committee, Department of Biostatistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran.
4- Department of Physiology, Faculty of Medicine, Student Research Committee, Dezful University of Medical Sciences, Dezful, Iran.
5- Department of Nursing, School of Nursing and Midwifery, Student Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
2- Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
3- MSc student of Biostatistics, Student Research Committee, Department of Biostatistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran.
4- Department of Physiology, Faculty of Medicine, Student Research Committee, Dezful University of Medical Sciences, Dezful, Iran.
5- Department of Nursing, School of Nursing and Midwifery, Student Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
Abstract:
Introduction: The most kind of dementia is senile dementia or Alzheimer's disease. Meanwhile, anticholinergic drugs can potentially modify the risk factors. As different studies have achieved different results and the clinical findings of these interventions have not been conclusive, the objective of this research will be to evaluate the effect of anticholinergic drugs on the risk of dementia.
Methods: This systematic review and meta-analysis with no language limitation between 1988.12.15 and 2021.12.15 will search WoS, EMBASE, and MEDLINE via PubMed, Scopus, ProQuest electronic databases and grey literature. Our search strategy with suitability criteria covers cohort, case-control, nested case-control, RCTs and non-randomized clinical trial studies evaluating the effect of anticholinergic drugs on the risk of dementia. Two authors will independently implement the selection phases, data extraction, and quality assessment. The reviewers will evaluate the risk of bias using Newcastle-Ottawa, Cochrane Risk of Bias Tool and (ROBINS-I) Quality Assessment Scale. We will conduct a meta-analysis with Random Effect Model or Fixed Effect Model according to severity of methodological heterogeneity. The results will be presented via the forest plot for the composition of final studies’ data, to demonstrate the separated and combined frequency and their corresponding 95% CIs and summary tables and narrative summaries.
Conclusion: The results of different studies in this field are various, where findings of this study, along with other studies, will help physicians and other health professionals before prescribing these drugs; the elderly, especially those with polypharmacy, should be carefully assessed for the risk of dementia, Alzheimer's or a variety of cognitive disorders
Methods: This systematic review and meta-analysis with no language limitation between 1988.12.15 and 2021.12.15 will search WoS, EMBASE, and MEDLINE via PubMed, Scopus, ProQuest electronic databases and grey literature. Our search strategy with suitability criteria covers cohort, case-control, nested case-control, RCTs and non-randomized clinical trial studies evaluating the effect of anticholinergic drugs on the risk of dementia. Two authors will independently implement the selection phases, data extraction, and quality assessment. The reviewers will evaluate the risk of bias using Newcastle-Ottawa, Cochrane Risk of Bias Tool and (ROBINS-I) Quality Assessment Scale. We will conduct a meta-analysis with Random Effect Model or Fixed Effect Model according to severity of methodological heterogeneity. The results will be presented via the forest plot for the composition of final studies’ data, to demonstrate the separated and combined frequency and their corresponding 95% CIs and summary tables and narrative summaries.
Conclusion: The results of different studies in this field are various, where findings of this study, along with other studies, will help physicians and other health professionals before prescribing these drugs; the elderly, especially those with polypharmacy, should be carefully assessed for the risk of dementia, Alzheimer's or a variety of cognitive disorders
Keywords: Anticholinergic Drug, Cholinergic Antagonist, Dementia, Alzheimer, Systematic Review, Meta-analysis
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