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1- Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Science, Tehran, Iran.
2- Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
3- Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
4- Department of Periodontics, School of Dentistry, Dental Research Center،Hamadan University of Medical Sciences, Hamadan, Iran.
5- Department of Biotechnology, Institute of Biochemical Procedures and Analyzes (IBVA). Technische Hochshule Mittelhessen Wiesenstr
6- Medwin Medical Center, Cell Therapy Department, Dubai, UAE.
Abstract:  
Introduction: Spinal cord injury (SCI) is characterized by serious both motor and sensory disability of the limbs below the injured segment. It is the most traumatic disorder among central nervous system (CNS) conditions that not only leads to psychological and physical harm to patients also results in a dramatic loss in life quality. Many efforts have been developed to find a therapeutic approach for SCI; however, an effective treatment has yet to be found.  The lack of effective treatment approach and rehabilitation of SCI underscores the need to identify the novel approaches. Tissue engineering associated with stem cells has been recently introduced as an effective treatment approach for traumatic SCI.  Although, low survival rates, immune rejection, cell dedifferentiation, and tumorigenicity have been addressed for tissue engneering. Regenerative medicine is an interdisciplinary field developing and applying tissue engineering, stem cell (SC) therapy, SC-derived extracellular vesicles therapy that aims to provide reliable and safe ways to replace the injured tissues and organs. The application of mesenchymal stem cells-derived extracellular vesicles (MSC-EVs) has been recently attracting attention to improve central nervous system dysfunction such as SCI, mainly through promoting neurogenesis and angiogenesis.
Conclusion: This study has summarized the efficacy of MSC-EVs, including exosomes, alone or in combination with scaffolds in treatment of SCI and has then discussed the therapeutic outcomes observed in SCI experimental models following treatment with MSC-EVs alone or loaded on scaffolds in particular collagen-based scaffolds.
Type of Study: Review | Subject: Behavioral Neuroscience
Received: 2021/08/27 | Accepted: 2021/12/4

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