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1- Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
3- Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:  
Introduction: It is reported that migraine may be risk factor of brain cancers. Since the one of the best ways to assess this possible relationship is molecular mechanism study, here the common central dysregulated proteins between these diseases are investigated via network analysis.
Methods: The dysregulated proteins of migraine and gliosarcoma are extracted from STRING database and interacted via Cytoscape software to form two separate networks. Central nodes of the networks are compared to find the common central differentially expressed proteins. First neighbors of the common central proteins are studied.   
Results: Numbers of 11 hub-bottlenecks for each one of migraine and gliosarcoma cancer networks were identified. Albumin and interleukin 6 as common differentially expressed central proteins were introduced. KNG1, VEGFA, and NF1 the first neighbors of ALB-IL6 were connected to the central nodes of networks of the two studied diseases.
Conclusion: Network analysis revealed that ALB and IL6 are common central dysregulate proteins between migraine and brain cancers. There are crucial proteins among the first neighbors of ALB and IL6 which are connected to migraine and gliosarcom.
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2021/08/6 | Accepted: 2021/08/15

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