Volume 13, Issue 6 (November & December 2022)
BCN 2022, 13(6): 893-900 |
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Mirfazeli F S, Mohebi F, Jahanbakhshi A, Aryani O, Almasi-Dooghaee M. Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior. BCN 2022; 13 (6) :893-900
URL: http://bcn.iums.ac.ir/article-1-2233-en.html
URL: http://bcn.iums.ac.ir/article-1-2233-en.html
Fatemeh Sadat Mirfazeli1 
, Fatemeh Mohebi2 , Amin Jahanbakhshi3 , Omid Aryani4 , Mostafa Almasi-Dooghaee * 5
, Fatemeh Mohebi2 , Amin Jahanbakhshi3 , Omid Aryani4 , Mostafa Almasi-Dooghaee * 5
1- Mental Health Research Center, Psychosocial Health Research Institute, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
3- Skull Base Research Center, Department of Neurosurgery, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
4- Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
5- Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
3- Skull Base Research Center, Department of Neurosurgery, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
4- Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
5- Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Abstract:
Wolfram syndrome (WS) is a rare autosomal recessive neurodegenerative disease with variable symptoms, including neuropsychiatric manifestations. A 26-year-old man was reported with classic symptoms of WS and repetitive psychiatric hospitalizations and at least 16 suicidal attempts. The genetic study demonstrated a novel homozygous stop-codon mutation on the WFS1 gene. This special type of mutation may be related to repetitive suicidal behaviors in this case of WS. Psychological support should be a routine practice in patients with WS.
Type of Study: Original |
Subject:
Clinical Neuroscience
Received: 2021/04/18 | Accepted: 2021/08/23 | Published: 2022/11/1
Received: 2021/04/18 | Accepted: 2021/08/23 | Published: 2022/11/1
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