Volume 14, Issue 1 (January & February-In Press 2023)
BCN 2023, 14(1): 0-0 |
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Olakunle Ishola A, Enitan Adetunji A, Chukwunwike Abanum I, Akorede Adeyemi A, Kenechukwu Faleye C, Babale Martins J, et al . Datumetine Preferentially Upregulates NMDAR Signalling Pathways in Different Brain Regions of Mice. BCN 2023; 14 (1)
URL: http://bcn.iums.ac.ir/article-1-2169-en.html
URL: http://bcn.iums.ac.ir/article-1-2169-en.html
Azeez Olakunle Ishola *1, Adedeji Enitan Adetunji1, Isaac Chukwunwike Abanum1, Adesola Akorede Adeyemi1, Caleb Kenechukwu Faleye1, Jane Babale Martins1, Nnenna Chimdalu Ogbe1, Toluwalase Cherish Ogundipe1, Karen Ezichi Okewulonu1, Umo Emmanuel Okon1, Deborah Irenoise Ovbude1, Richard Yomi Akele2, Naeemat Tolulope Omotade3, Moyosore Salihu Ajao4
1- Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti Nigeria.
2- Department of Medical Laboratory Science, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti Nigeria.
3- Department of Anatomy, College of Health Technology Ijero-Ekiti, Nigeria.
4- Department of Anatomy, University of Ilorin, Ilorin Nigeria.
2- Department of Medical Laboratory Science, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti Nigeria.
3- Department of Anatomy, College of Health Technology Ijero-Ekiti, Nigeria.
4- Department of Anatomy, University of Ilorin, Ilorin Nigeria.
Abstract:
Background: We earlier reported that datumetine possesses binding affinity with NMDAR and that 14-day exposure to datumetine altered NMDAR signalling by mimicking glutamate toxicity. Here, we investigated the potential neuroprotective effect of a single shot of a low dose of datumetine administration in BALB/c mice.
Results: Relative to Veh, datumetine downregulate the expression of CamKIIα in the hippocampus and PFC but not in the cerebellum, CREB was also upregulated in the PFC only, but pCREB was also upregulated in all the three brain regions observed, while BDNF was only upregulated in both hippocampus and PFC of Datumetine relative to Veh. MK-801 on the other hand reversed some of the effects of datumetine in the brain regions observed. No major histological alterations were observed in the different brain regions immunohistochemically.
Conclusion: We conclude that a single low dose of datumetine moderately enhances NMDAR activity. This showed the neuroprotective potentials of low datumetine exposure.
Results: Relative to Veh, datumetine downregulate the expression of CamKIIα in the hippocampus and PFC but not in the cerebellum, CREB was also upregulated in the PFC only, but pCREB was also upregulated in all the three brain regions observed, while BDNF was only upregulated in both hippocampus and PFC of Datumetine relative to Veh. MK-801 on the other hand reversed some of the effects of datumetine in the brain regions observed. No major histological alterations were observed in the different brain regions immunohistochemically.
Conclusion: We conclude that a single low dose of datumetine moderately enhances NMDAR activity. This showed the neuroprotective potentials of low datumetine exposure.
Type of Study: Original |
Subject:
Behavioral Neuroscience
Received: 2021/05/13 | Accepted: 2021/06/30 | Published: 2023/01/12
Received: 2021/05/13 | Accepted: 2021/06/30 | Published: 2023/01/12
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