Accepted Articles                   Back to the articles list | Back to browse issues page


XML Print


1- Medical Consultant,Clinical genetics,Institute of Genetics and Hospital for genetic diseases,Telangana,India
2- Assistant Professor,Department of Biochemistry, ESIC Medical College and Hospital, Sanathnagar,Telangana,India
3- Senior Medical Consultant,Clinical genetics,Institute of Genetics and Hospital for Genetic Diseases,Telangana,India
4- Assistant Professor & Incharge,Cell biology,Institute of Genetics and Hospital for Genetic Diseases,Telangana,India
5- Medical Consultant,Clinical genetics,Institute of Genetics and Hospital for Genetic Diseases,Telangana,India
6- Medical Consultant,Clinical genetics,Institute of Genetics and Hospital for Genetic Diseases,Telangana,India.
Abstract:  
Background:Dyslexia is a typical learning disability that does not affect intelligence but causes problems with reading, writing, and spelling. It is influenced by certain genes, due to which several researchers have attempted to identify the susceptible gene. Dyslexia is incurable and diagnosis is difficult because it always overlaps with other learning disabilities. Hence, timely assessment and intervention consequently give the best results. Therefore, our aim was to find the relation between dyslexia and single nucleotide polymorphisms (SNPs) in several candidate genes like DYX1C1, KIAA0319, and DCDC2 in Indian population.
Methods:In the present study, 103 individuals with dyslexia and 100 controls in the age group between 6 to 15 years were taken. Thirteen SNPs in the KIAA gene, seven SNPs of DCDC2, and three SNPs of the DYX1C1 gene were analysed by the Mass Array technique.
Results:The association of dyslexia with SNPs rs3756821, rs6935076, rs4576240 of the KIAA gene was found significant. A significant association was found with rs600753 of the DYX1C1 gene and dyslexia and we could not find any association of the DCDC2 gene with dyslexia.
Conclusions:Prerequisite genetic analysis is necessary for the diagnosis of dyslexia as it is a crucial educational barrier. Treatment is known to be most effective if dyslexia is identified in the early stages for effective intervention for children before they experience prolonged reading failure. Further, it helps in prenatal diagnosis for early intervention.
Type of Study: Original | Subject: Cellular and molecular Neuroscience
Received: 2021/02/17 | Accepted: 2021/06/28

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb