Volume 13, Issue 4 (July & August: Special Issue on Cognitive Sciences 2022)
BCN 2022, 13(4): 519-530 |
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Azizi E, Ayoobi F, Shamsizadeh A, Moghadam-Ahmadi A, Shafiei S A, Khoshdel A et al . Effect of Short-time Exposure of Local Extremely Low-Frequency Magnetic Fields on Sleepiness in Male Rats. BCN 2022; 13 (4) :519-530
URL: http://bcn.iums.ac.ir/article-1-1805-en.html
URL: http://bcn.iums.ac.ir/article-1-1805-en.html
Elnaz Azizi1 
, Fatemeh Ayoobi1 , Ali Shamsizadeh2 , Amir Moghadam-Ahmadi1 , Seyed Ali Shafiei * 3, Alireza Khoshdel4 , Mohammad Reza Mirzaei5
, Fatemeh Ayoobi1 , Ali Shamsizadeh2 , Amir Moghadam-Ahmadi1 , Seyed Ali Shafiei * 3, Alireza Khoshdel4 , Mohammad Reza Mirzaei5
1- Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
2- Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
3- Neuroscience Research Center, Qom University of Medical Sciences, Qom, Iran.
4- Department of Biochemistry, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
5- Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
2- Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
3- Neuroscience Research Center, Qom University of Medical Sciences, Qom, Iran.
4- Department of Biochemistry, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
5- Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Abstract:
Introduction: Lack of high-quality sleep causes severe side effects like anxiety and changes in plasma concentration of oxalate. The current study investigated the impact of local extremely low-frequency magnetic fields (ELF-MFs) on inducing sleep (sleepiness) and anxiety in male rats.
Methods: In this experimental study, 40 male rats were divided into four groups (n=10 for each group). The ELF-MF exposure (0, 10, and 18 Hz) was applied with an intensity of 200µT for three days (10 min/d). The sham-treated animal did not receive ELF-MF. Serum levels of oxalic acid (OA) and sleepiness were measured before and after the last exposure to ELF-MF or sham. Anxiety, sleepiness, and OA were measured using the elevated plus maze, open-field test (OFT), and ELISA test.
Results: A comparison of oxalate levels before and after exposure to ELF-MF revealed that ELF-MF (10 Hz) decreased the serum level of oxalate (P<0.05). Comparing open/closed arm entry (in an elevated plus maze) between before and after exposure to ELF-MF revealed significant differences. Also, frequency, velocity, and distance moved were decreased in the open-field test.
Conclusion: Results of the present study demonstrated that ELF-MF with short-time exposure may modulate the metabolism of OA and may modulate anxiety-like behavior or kind of induction of sleepiness in male rats.
Methods: In this experimental study, 40 male rats were divided into four groups (n=10 for each group). The ELF-MF exposure (0, 10, and 18 Hz) was applied with an intensity of 200µT for three days (10 min/d). The sham-treated animal did not receive ELF-MF. Serum levels of oxalic acid (OA) and sleepiness were measured before and after the last exposure to ELF-MF or sham. Anxiety, sleepiness, and OA were measured using the elevated plus maze, open-field test (OFT), and ELISA test.
Results: A comparison of oxalate levels before and after exposure to ELF-MF revealed that ELF-MF (10 Hz) decreased the serum level of oxalate (P<0.05). Comparing open/closed arm entry (in an elevated plus maze) between before and after exposure to ELF-MF revealed significant differences. Also, frequency, velocity, and distance moved were decreased in the open-field test.
Conclusion: Results of the present study demonstrated that ELF-MF with short-time exposure may modulate the metabolism of OA and may modulate anxiety-like behavior or kind of induction of sleepiness in male rats.
Keywords: Magnetic field, Extremely low-frequency magnetic fields (ELF-MFs), Oxalic acid, Anxiety, Sleepiness
Type of Study: Original |
Subject:
Cognitive Neuroscience
Received: 2020/06/2 | Accepted: 2020/11/1 | Published: 2022/07/24
Received: 2020/06/2 | Accepted: 2020/11/1 | Published: 2022/07/24
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