Volume 2, Issue 4 (Summer 2011 -- 2011)                   BCN 2011, 2(4): 47-52 | Back to browse issues page

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Hosseini M, Feizpour A, Rezaeipour M, Amani A, Saffarzadeh F, Farrokhi E. Chronic Treatment by L-NAME differently Affects Morris Water Maze Tasks in Ovariectomized and Naïve Female Rats. BCN 2011; 2 (4) :47-52
URL: http://bcn.iums.ac.ir/article-1-178-en.html
Chronic Treatment by L-NAME differently Affects Morris Water Maze Tasks in Ovariectomized and Naïve Female Rats
Mahmoud Hosseini * , Azadeh Feizpour , Mohsen Rezaeipour , Atefeh Amani , Fatima Saffarzadeh , Esmaeil Farrokhi
Abstract:  

Introduction: The role of ovarian hormones and nitric oxide (NO) in learning and memory and their interaction has been widely investigated. The present study carried out to evaluate different effect of L-NAME on spatial learning and memory of ovariectomized (OVX) and sham operated rats.

Methods:

32 rats were divided into 4 groups: 1) Sham 2) OVX 3) Sham-LN and 4) OVX-LN. The animals of groups 3 and 4 were treated by L-NAME (10 mg/kg/ day) for 8 weeks while the animals of groups 1 and 2 received saline (1ml/kg/day) instead of L-NAME. The animals of all groups were then tested in Morris water maze during five days. The escape latency and traveled distance were compared between groups.

Results:

Distance and time in OVX group was significantly higher than Sham group (p<0.01 and p<0.05). Time and distance in Sham-LN group was higher in comparison with Sham group (p<0.05 and p<0.01). There were no significant differences between OVX-LN and OVX groups in escape latency and traveled distance.

Discussion:

The results of present study showed that removal of ovarian hormones could impair Morris water maze tskas includiong time and distance. Administarion of non specific nitricoxide inhibitor, L-NAME, affects Morrsi water maze tasks however, its effect is different in the absence and presence of ovarian hormones but it needs to be more investigated.

Keywords: Ovariectomy, Female Rat, Morris Water Maze, Morris Water Maze
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Type of Study: Original | Subject: Clinical Neuroscience
Received: 2012/03/5 | Published: 2011/08/15
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