Volume 13, Issue 4 (July & August: Special Issue on Cognitive Sciences 2022)
BCN 2022, 13(4): 501-510 |
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Mandegary A, Sharififar F, Sheibani V, Nasehi N, Asadi A, Mirtadzadini M et al . Ameliorating Effect of Standardized Extract From Textured Soy Protein (Glycine max L.) on Memory Deficit and Learning Insufficiency in Scopolamine-induced Amnesia. BCN 2022; 13 (4) :501-510
URL: http://bcn.iums.ac.ir/article-1-1729-en.html
URL: http://bcn.iums.ac.ir/article-1-1729-en.html
Ali Mandegary1 
, Fariba Sharififar * 2, Vahid Sheibani3 , Naghmeh Nasehi2 , Amir Asadi4 , Mansour Mirtadzadini4 , Navid Hassanabadi5
, Fariba Sharififar * 2, Vahid Sheibani3 , Naghmeh Nasehi2 , Amir Asadi4 , Mansour Mirtadzadini4 , Navid Hassanabadi5
1- Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
2- Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
3- Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
4- Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.
5- School of Veterinary, Shahid Bahonar University of Kerman, Kerman, Iran.
2- Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
3- Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
4- Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.
5- School of Veterinary, Shahid Bahonar University of Kerman, Kerman, Iran.
Abstract:
Introduction: Textured soy protein (TSP) and nuts are two processed forms of soybean (Glycine max L.) that are widely consumed for nutritional purposes in Iran. Recently, we have reported the antioxidant and anticholinesterase effects of raw soybean (RS) attributed to isoflavones, such as genistein. In this work, we aimed to compare in vitro antioxidant and anticholinesterase effects of TSP, nuts, and RS to select the most effective one for learning capacity and spatial memory studies.
Methods: Genistein content was determined using high-performance thin layer chromatography (HPTLC), while diphenylpicrylhydrazil (DPPH) radical scavenging and ferric reducing antioxidant power (FRAP) were used to study antioxidant evaluation and Ellman’s colorimetric method was used to measure anticholinesterase. TSP extract (TSPE) was administered to male rats (100 mg/kg, 200 mg/kg and 400 mg/kg, intraperitoneally [i.p] for 7 days) before scopolamine injection (1 mg/kg). Learning capacity and spatial memory were evaluated using passive avoidance test (PAT) and Morris water maze (MWM) methods compared to physostigmine and piracetam.
Results: The greatest antioxidant and anticholinesterase effect was observed for TSPE, which significantly prolonged initially latency in PTA (P<0.05) and improved all indicators in the MWM test at 200 mg/kg.
Conclusion: The memory-improving effect of TSPE may be due to its antioxidant and anticholinesterase effect as well as neuroprotective effects of its isoflavones.
Methods: Genistein content was determined using high-performance thin layer chromatography (HPTLC), while diphenylpicrylhydrazil (DPPH) radical scavenging and ferric reducing antioxidant power (FRAP) were used to study antioxidant evaluation and Ellman’s colorimetric method was used to measure anticholinesterase. TSP extract (TSPE) was administered to male rats (100 mg/kg, 200 mg/kg and 400 mg/kg, intraperitoneally [i.p] for 7 days) before scopolamine injection (1 mg/kg). Learning capacity and spatial memory were evaluated using passive avoidance test (PAT) and Morris water maze (MWM) methods compared to physostigmine and piracetam.
Results: The greatest antioxidant and anticholinesterase effect was observed for TSPE, which significantly prolonged initially latency in PTA (P<0.05) and improved all indicators in the MWM test at 200 mg/kg.
Conclusion: The memory-improving effect of TSPE may be due to its antioxidant and anticholinesterase effect as well as neuroprotective effects of its isoflavones.
Keywords: Alzheimer’s disease, Dementia, Textured soy protein, Morris water maze, Antioxidant, Scopolamine
Type of Study: Original |
Subject:
Cognitive Neuroscience
Received: 2020/03/14 | Accepted: 2020/12/15 | Published: 2022/07/24
Received: 2020/03/14 | Accepted: 2020/12/15 | Published: 2022/07/24
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