Volume 13, Issue 3 (May & Jun 2022)                   BCN 2022, 13(3): 357-372 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Karimifar K, Alipanah H, Solatani Hekmat A, Bigdeli M R. Attenuating NF-κB/VCAM-1 Expression in the Middle Cerebral Artery Occlusion Model by Viola Odorata: Protection Against Ischemia-Reperfusion Injury in Rats. BCN 2022; 13 (3) :357-372
URL: http://bcn.iums.ac.ir/article-1-1609-en.html
1- Department of Physiology, Faculty of life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
2- Department of Physiology, Faculty of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
Introduction: The death of neurons and cerebral edema are the main consequences of stroke. However, inflammatory processes play key roles in aggravating cerebral damage following a stroke. This study aimed to investigate the effects of Viola odorata extract (VOE) on the infarct volume (IV), neurologic deficits (ND), and the expression of NF-κB and VCAM-1 in the Middle Cerebral Artery Occlusion (MCAO) model.
Methods: The animals were randomly separated into 6 groups: (1) control group, (2) vehicle-treated group, (3) MCAO group, (4) VOE25 group, (5) VOE50 group, and (6) VOE75 group (n= 12). VOE (25, 50, and 75 mg/kg) and distilled water were administered daily for 30 days. Two hours after the last gavage, the rats were exposed to MCAO for 60 minutes. Twenty-four hours later, IV, ND, and NF-κB/VCAM-1 expressions were evaluated.
Results: Viola odorata extract exhibited excellent neuroprotective effects by reducing IV (mainly in the core and subcortex areas), and induced downregulation of NF-κB and VCAM-1 expression.
Conclusion: Viola odorata could also activate intracellular pathways, reducing the expression of NF-κB and VCAM-1. It is useful for developing a novel medical herb for treating cerebral ischemia.
Type of Study: Original | Subject: Cellular and molecular Neuroscience
Received: 2019/09/23 | Accepted: 2020/08/25 | Published: 2022/05/1

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb