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1- Control and Intelligent Processing Center of Excellence, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Abstract:
Introduction: Functional Near-Infrared Spectroscopy (fNIRS) is an imaging method in which light source and detector are installed on the head; consequently, re-emission of light from human skin contains information about cerebral hemodynamic alteration. The spatial probability distribution profile of photons penetrating tissue at a source spot, scattering into the tissue, and being released at an appropriate detector position, represents the spatial sensitivity.
Method: Modeling light propagation in a human head is essential for quantitative near-infrared spectroscopy and optical imaging. The specific form of the distribution of light is obtained using the theory of perturbation. Analytical solution of the perturbative Diffusion Equation (DE) and Finite Element Method (FEM) in a Slab media (similar to the human head) makes it possible to study light propagation due to absorption and scattering of brain tissue.
Results: The simulation result indicates that sensitivity is slowly decreasing in the deep area, and the sensitivity below the source and detector is the highest. The depth sensitivity and computation time of both Analytical and FEM methods are compared. The simulation time of the analytical approach is four orders of magnitude faster than the FEM.
Conclusion: In this paper, an analytical solution and FEM methods performance when applied to the diffusion equation for heterogeneous media with a single spherical defect are compared. The depth sensitivity, along with the computation time of simulation, has been investigated for both methods. For simple and Slab-like human brain models, the analytical solution is the right candidate. Whenever the brain model is sophisticated, it is possible to use FEM methods, but it costs higher computation time.
Method: Modeling light propagation in a human head is essential for quantitative near-infrared spectroscopy and optical imaging. The specific form of the distribution of light is obtained using the theory of perturbation. Analytical solution of the perturbative Diffusion Equation (DE) and Finite Element Method (FEM) in a Slab media (similar to the human head) makes it possible to study light propagation due to absorption and scattering of brain tissue.
Results: The simulation result indicates that sensitivity is slowly decreasing in the deep area, and the sensitivity below the source and detector is the highest. The depth sensitivity and computation time of both Analytical and FEM methods are compared. The simulation time of the analytical approach is four orders of magnitude faster than the FEM.
Conclusion: In this paper, an analytical solution and FEM methods performance when applied to the diffusion equation for heterogeneous media with a single spherical defect are compared. The depth sensitivity, along with the computation time of simulation, has been investigated for both methods. For simple and Slab-like human brain models, the analytical solution is the right candidate. Whenever the brain model is sophisticated, it is possible to use FEM methods, but it costs higher computation time.
Type of Study: Original |
Subject:
Computational Neuroscience
Received: 2019/07/11 | Accepted: 2020/11/14
Received: 2019/07/11 | Accepted: 2020/11/14
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Contact Information
Basic and Clinical Neuroscience Journal (BCN)
Iran University of Medical Sciences, Shahid Hemmat Highway, Tehran, Iran.
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