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1- Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin, P.M.B., Ilorin.
Abstract:  
Introduction: The neurotoxic effects of aluminium exposure during the critical period of neurodevelopment has been well documented. This study investigated the putative protective effects of calcium supplementation on the cerebellum of juvenile Wistar rats following aluminium-induced neurotoxicity during lactation.
Methods: Four groups of juvenile rats were exposed via lactation to distilled water (control group), aluminium (40 mg/kg/d), calcium supplement (50 mg/kg/d), and a combination of both aluminium and calcium from postnatal day 4 to 28. The cerebella of the animals were excised to access the levels of antioxidant enzymes (SOD and GPx), lipid peroxidation (MDA), histomorphological alterations (H and E), Nissl profile (CFV) and glial activation (GFAP immunohistochemistry).
Results: Lactational aluminium significantly decreased the activities of superoxide dismutase and glutathione peroxidase while exacerbating lipid peroxidation and reactive astrocyte in cerebellar lysates. Lactational calcium supplementation normalized the activities of SOD and GPx, thereby preventing excessive lipid peroxidation and glial activation. Despite no apparent changes in the general histology of the cerebellum, aluminium induced chromatolytic changes in the Purkinje cell layer, which was counteracted by the antioxidant propensities of calcium supplementation.
Conclusion: These findings support that calcium supplementation significantly protected the cerebellum against Al-induced oxidative stress, chromatolysis, and neuroinflammation.
Type of Study: Original | Subject: Cellular and molecular Neuroscience
Received: 2019/05/1 | Accepted: 2020/08/26

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