The Effect of the Flavonoid Quercetin on Pain Sensation in Diabetic Rats

Narenjkar, Jamshid; Roghani, Mehrdad; Alambeygi, Hanieh; Sedaghati, Farnoosh

Volume 2, Issue 3 (Spring 2011 -- 2011) BCN 2011, 2(3): 51-57 | Back to browse issues page

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Narenjkar J, Roghani M, Alambeygi H, Sedaghati F. The Effect of the Flavonoid Quercetin on Pain Sensation in Diabetic Rats. BCN 2011; 2 (3) :51-57
URL: http://bcn.iums.ac.ir/article-1-146-en.html

The Effect of the Flavonoid Quercetin on Pain Sensation in Diabetic Rats

Jamshid Narenjkar ^*

, Mehrdad Roghani

, Hanieh Alambeygi

, Farnoosh Sedaghati

Abstract:

Introduction:
Hyperalgesia is considered as one of the marked signs of subchronic diabetes mellitus in patients that could affect their lifestyle. This study was designed to investigate the anti-nociceptive effect of chronic administration of quercetin in streptozotocin (STZ)-diabetic rats using formalin and hot tail immersion tests. Methods:
Rats were divided into control, control or diabetic groups receiving sodium salicylate, untreated diabetic, and quercetin-treated control and diabetic groups. The treatment groups received i.p. administration of quercetin at a dose of 10 mg/kg for 6 weeks. Finally, hyperalgesia were assessed using standard formalin and hot tail immersion tests. Meanwhile, some markers of oxidative stress were also measured in brain tissue.
Results:
Quercetin or SS treatment of diabetic rats significantly reduced pain score in chronic phase of formalin test (p<0.05). Regarding hot tail immersion test, diabetic rats showed a significant reduction in tail flick latency as compared to control ones (p<0.05) and quercetin treatment of diabetic rats did significantly increase this latency relative to untreated diabetics (p<0.05). Quercetin treatment of diabetic rats also significantly decreased brain level of malondialdehyde (MDA) (p<0.05) and nitrite (p<0.05) and slightly increased activity of superoxide dismutase (SOD) relative to diabetics. Discussion:
Taken together, chronic administration of quercetin could attenuate nociceptive score in chronic phase of formalin test in streptozotocin-diabetic rats and could also increase threshold of thermal nociception.
　
　

Keywords: Quercetin, Diabetes Mellitus, Antinociception, Formalin Test, Hot Tail Immersion Test, Oxidative Stressof

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Type of Study: Original | Subject: Clinical Neuroscience
Received: 2012/01/3 | Published: 2011/04/15

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